Fertilizer type affects stable isotope ratios of nitrogen in human blood plasma - results from two-year controlled agricultural field trials and a randomized crossover dietary intervention study
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- Mie et al_Agricultural and Food Chemistry_2022_Vol 70(11)_3391-3399
Final published version, 1.33 MB, PDF document
The stable nitrogen isotope ratio δ15N is used as a marker of dietary protein sources in blood. Crop fertilization strategies affect δ15N in plant foods. In a double-blinded randomized cross-over dietary intervention trial with 33 participants, we quantified the effect of fertilizer type (conventional: synthetic fertilizer and organic: animal or green manure) on δ15N in blood plasma. At study baseline, plasma δ15N was +9.34 ± 0.29‰ (mean ± standard deviation). After 12 days intervention with a diet based on crops fertilized with animal manure, plasma δ15N was shifted by +0.27 ± 0.04‰ (mean ± standard error) compared to synthetic fertilization and by +0.22 ± 0.04‰ compared to fertilization with green manure (both p < 0.0001). Accordingly, differences in the δ15N values between fertilizers are propagated to the blood plasma of human consumers. The results indicate a need to consider agricultural practices when using δ15N as a dietary biomarker.
Original language | English |
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Journal | Journal of Agricultural and Food Chemistry |
Volume | 70 |
Issue number | 11 |
Pages (from-to) | 3391-3399 |
Number of pages | 9 |
ISSN | 0021-8561 |
DOIs | |
Publication status | Published - 2022 |
- Faculty of Science - Dietary protein, Fertilizer type, Organic food, Production systems, Stable nitrogen isotopes
Research areas
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