Hemostatic biomarkers in dogs with chronic congestive heart failure
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Hemostatic biomarkers in dogs with chronic congestive heart failure. / Tarnow, Inge; Falk, Torkel; Tidholm, Anna; Martinussen, Torben; Jensen, Asger Lundorff; Olsen, Lisbeth Høier; Pedersen, Henrik Duelund; Kristensen, Annemarie Thuri.
In: Journal of Veterinary Internal Medicine, Vol. 21, No. 3, 2007, p. 451-457.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Hemostatic biomarkers in dogs with chronic congestive heart failure
AU - Tarnow, Inge
AU - Falk, Torkel
AU - Tidholm, Anna
AU - Martinussen, Torben
AU - Jensen, Asger Lundorff
AU - Olsen, Lisbeth Høier
AU - Pedersen, Henrik Duelund
AU - Kristensen, Annemarie Thuri
PY - 2007
Y1 - 2007
N2 - Background: Chronic congestive heart failure (CHF) in humans is associated with abnormal hemostasis, and abnormalities in hemostatic biomarkers carry a poor prognosis. Alterations in hemostatic pathways can be involved in the pathogenesis of CHF in dogs, and microthrombosis in the myocardium could contribute to increased mortality.Hypothesis: That plasma concentration or activity of hemostatic biomarkers is altered in dogs with CHF and that these factors predict mortality.Animals: Thirty-four dogs with CHF caused by either dilated cardiomyopathy (DCM, n = 14) or degenerative valvular disease (CDVD, n = 20) compared with 23 healthy age-matched control dogs were included in this study. Dogs with CHF were recruited from 2 referral cardiology clinics, and control dogs were owned by friends or colleagues of the investigators.Methods: Clinical examination and echocardiography were performed in all dogs. Plasma fibrinogen and D-dimer concentrations, antithrombin and protein C activity, and thrombin-antithrombin complex (TAT) were measured in all dogs.Results: Dogs with CHF had significantly higher fibrinogen (P = .04), D-dimer (P = .002), and TAT concentration (P < .0001), lower antithrombin (P < .0001) and protein C activity (P < .001) compared with control dogs. None of the memostatic biomarkers were associated with risk of death.Conclusions and Clinical Importance: There is evidence of a procoagulant state in dogs with CHF. The lack of predictive value for survival might be due to the small number of dogs examined. Further studies are necessary to investigate the presence and importance of microthrombosis in dogs with CHF.
AB - Background: Chronic congestive heart failure (CHF) in humans is associated with abnormal hemostasis, and abnormalities in hemostatic biomarkers carry a poor prognosis. Alterations in hemostatic pathways can be involved in the pathogenesis of CHF in dogs, and microthrombosis in the myocardium could contribute to increased mortality.Hypothesis: That plasma concentration or activity of hemostatic biomarkers is altered in dogs with CHF and that these factors predict mortality.Animals: Thirty-four dogs with CHF caused by either dilated cardiomyopathy (DCM, n = 14) or degenerative valvular disease (CDVD, n = 20) compared with 23 healthy age-matched control dogs were included in this study. Dogs with CHF were recruited from 2 referral cardiology clinics, and control dogs were owned by friends or colleagues of the investigators.Methods: Clinical examination and echocardiography were performed in all dogs. Plasma fibrinogen and D-dimer concentrations, antithrombin and protein C activity, and thrombin-antithrombin complex (TAT) were measured in all dogs.Results: Dogs with CHF had significantly higher fibrinogen (P = .04), D-dimer (P = .002), and TAT concentration (P < .0001), lower antithrombin (P < .0001) and protein C activity (P < .001) compared with control dogs. None of the memostatic biomarkers were associated with risk of death.Conclusions and Clinical Importance: There is evidence of a procoagulant state in dogs with CHF. The lack of predictive value for survival might be due to the small number of dogs examined. Further studies are necessary to investigate the presence and importance of microthrombosis in dogs with CHF.
KW - Former LIFE faculty
KW - Chronic valvular disease
KW - Coagulation
KW - Dilated cardiomyopathy
KW - Thrombosis
U2 - 10.1111/j.1939-1676.2007.tb00818.x
DO - 10.1111/j.1939-1676.2007.tb00818.x
M3 - Journal article
VL - 21
SP - 451
EP - 457
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 3
ER -
ID: 8073216