Hypophosphatemia after hemodialysis and its association with some clinical complications in patients with chronic kidney disease
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Hypophosphatemia after hemodialysis and its association with some clinical complications in patients with chronic kidney disease. / Ardalan, Mohammadreza; Safaei, Ali; Tolouian, Audrey; Tolouian, Ramin; Ebrahimzadeh Attari, Vahideh ; Jalili, Mahsa.
In: Caspian Journal of Internal Medicine, Vol. 13, No. 3, 2022, p. 527-532.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Hypophosphatemia after hemodialysis and its association with some clinical complications in patients with chronic kidney disease
AU - Ardalan, Mohammadreza
AU - Safaei, Ali
AU - Tolouian, Audrey
AU - Tolouian, Ramin
AU - Ebrahimzadeh Attari, Vahideh
AU - Jalili, Mahsa
N1 - (Ekstern)
PY - 2022
Y1 - 2022
N2 - Background: Beyond the adverse effects of hyperphosphatemia in patients with chronic kidney disease (CKD(, hypophosphatemia has also been proposed as a common challenge after dialysis. Therefore, the present study aimed to evaluate the serum phosphate level immediately after hemodialysis (HD) and its association with some clinical complications in CKD patients. Methods: The present cross-sectional study was conducted on 54 eligible CKD patients undergoing regular hemodialysis. Blood samples were taken, prior to the start and immediately after the end of hemodialysis to determine the serum levels of urea, creatinine, sodium, potassium, phosphorus, PTH, blood sugar and albumin. Moreover, the clinical complications of patients including muscle cramps, nausea, vomiting, headache, confusion, weakness and inability to speak are assessed by a questionnaire, before and after HD.Results: As we expected, the mean of serum creatinine, urea and phosphate levels significantly decreased after dialysis. Post-dialysis hypophosphatemia was graded as mild (3.5 > P ≥ 2.5 mg/dl), moderate (2.5 > P ≥ 1 mg/dl), and severe (<1 mg/dl) based on serum phosphate levels. The frequency of mild and moderate hypophosphatemia was 39.2% and 45.1 %, respectively. None of the participants had severe hypophosphatemia and 13.7% had normal phosphate levels. There was a significant correlation between post-dialysis hypophosphatemia and incidence of nausea and confusion after adjusting for confounding factors.Conclusion: To our knowledge, this is the first time that the possible association of some of the post-dialysis clinical complications with hypophosphatemia was investigated. Future large-scale studies are required to confirm the association of post-dialysis hypophosphatemia with clinical complications.
AB - Background: Beyond the adverse effects of hyperphosphatemia in patients with chronic kidney disease (CKD(, hypophosphatemia has also been proposed as a common challenge after dialysis. Therefore, the present study aimed to evaluate the serum phosphate level immediately after hemodialysis (HD) and its association with some clinical complications in CKD patients. Methods: The present cross-sectional study was conducted on 54 eligible CKD patients undergoing regular hemodialysis. Blood samples were taken, prior to the start and immediately after the end of hemodialysis to determine the serum levels of urea, creatinine, sodium, potassium, phosphorus, PTH, blood sugar and albumin. Moreover, the clinical complications of patients including muscle cramps, nausea, vomiting, headache, confusion, weakness and inability to speak are assessed by a questionnaire, before and after HD.Results: As we expected, the mean of serum creatinine, urea and phosphate levels significantly decreased after dialysis. Post-dialysis hypophosphatemia was graded as mild (3.5 > P ≥ 2.5 mg/dl), moderate (2.5 > P ≥ 1 mg/dl), and severe (<1 mg/dl) based on serum phosphate levels. The frequency of mild and moderate hypophosphatemia was 39.2% and 45.1 %, respectively. None of the participants had severe hypophosphatemia and 13.7% had normal phosphate levels. There was a significant correlation between post-dialysis hypophosphatemia and incidence of nausea and confusion after adjusting for confounding factors.Conclusion: To our knowledge, this is the first time that the possible association of some of the post-dialysis clinical complications with hypophosphatemia was investigated. Future large-scale studies are required to confirm the association of post-dialysis hypophosphatemia with clinical complications.
KW - Faculty of Science
KW - Dialysis
KW - Hypophosphatemia
KW - Nausea
KW - Chronic kidney disease
U2 - 10.22088/cjim.13.3.527
DO - 10.22088/cjim.13.3.527
M3 - Journal article
C2 - 35974934
VL - 13
SP - 527
EP - 532
JO - Caspian Journal of Internal Medicine
JF - Caspian Journal of Internal Medicine
SN - 2008-6164
IS - 3
ER -
ID: 312124107