IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes
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IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes. / Falkencrone, Sidsel; Poulsen, Lars K.; Bindslev-Jensen, Carsten; Andersen, Anders Woetmann; Ødum, Niels; Poulsen, Britta Cathrina; Blom, L.; Jensen, B. M.; Gibbs, B. F.; Yasinska, I. M.; Sumbayev, V. V.; Skov, P. S.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 68, No. 5, 2013, p. 614-620.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes
AU - Falkencrone, Sidsel
AU - Poulsen, Lars K.
AU - Bindslev-Jensen, Carsten
AU - Andersen, Anders Woetmann
AU - Ødum, Niels
AU - Poulsen, Britta Cathrina
AU - Blom, L.
AU - Jensen, B. M.
AU - Gibbs, B. F.
AU - Yasinska, I. M.
AU - Sumbayev, V. V.
AU - Skov, P. S.
N1 - © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
PY - 2013
Y1 - 2013
N2 - IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
AB - IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
KW - Faculty of Health and Medical Sciences
KW - Basophils
KW - IgE-mediated activation
KW - monocytes
KW - tissue remodelling
KW - TNF-alpha
U2 - 10.1111/all.12143
DO - 10.1111/all.12143
M3 - Journal article
C2 - 23573943
VL - 68
SP - 614
EP - 620
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 5
ER -
ID: 45791918