Library of biphenyl privileged substructures using a safety-catch linker approach
Research output: Contribution to journal › Journal article › Research › peer-review
A biphenyl privileged structure library containing three attachment points were synthesized using a catechol-based safety-catch linker strategy. The method requires the attachment of a bromo-acid to the linker, followed by a Pd-catalyzed Suzuki cross-coupling reaction. Further derivatization, activation of the linker with strong acid and aminolysis afforded the respective products in high purity and good overall yield. To show the versatility of the synthesis, a 199-member library was generated. The library samples both conformational and chemical diversity about a well-known privileged substructure.
Original language | English |
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Journal | Journal of Combinatorial Chemistry |
Volume | 10 |
Issue number | 4 |
Pages (from-to) | 557-566 |
ISSN | 1520-4766 |
DOIs | |
Publication status | Published - 2008 |
Bibliographical note
Keywords: Biphenyl Compounds; Catalysis; Combinatorial Chemistry Techniques; Cross-Linking Reagents; Molecular Structure
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 10113426