Maternal milk microbiota and oligosaccharides contribute to the infant gut microbiota assembly
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Maternal milk microbiota and oligosaccharides contribute to the infant gut microbiota assembly. / Laursen, Martin Frederik; Pekmez, Ceyda Tugba; Larsson, Melanie Wange; Lind, Mads Vendelbo; Yonemitsu, Chloe; Larnkjær, Anni; Mølgaard, Christian; Bode, Lars; Dragsted, Lars Ove; Michaelsen, Kim F.; Licht, Tine Rask; Bahl, Martin Iain.
In: ISME Communications, Vol. 1, 21, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal milk microbiota and oligosaccharides contribute to the infant gut microbiota assembly
AU - Laursen, Martin Frederik
AU - Pekmez, Ceyda Tugba
AU - Larsson, Melanie Wange
AU - Lind, Mads Vendelbo
AU - Yonemitsu, Chloe
AU - Larnkjær, Anni
AU - Mølgaard, Christian
AU - Bode, Lars
AU - Dragsted, Lars Ove
AU - Michaelsen, Kim F.
AU - Licht, Tine Rask
AU - Bahl, Martin Iain
N1 - CURIS 2021 NEXS 277
PY - 2021
Y1 - 2021
N2 - Breastfeeding protects against diseases, with potential mechanisms driving this being human milk oligosaccharides (HMOs) and the seeding of milk-associated bacteria in the infant gut. In a cohort of 34 mother–infant dyads we analyzed the microbiota and HMO profiles in breast milk samples and infant’s feces. The microbiota in foremilk and hindmilk samples of breast milk was compositionally similar, however hindmilk had higher bacterial load and absolute abundance of oral-associated bacteria, but a lower absolute abundance of skin-associated Staphylococcus spp. The microbial communities within both milk and infant’s feces changed significantly over the lactation period. On average 33% and 23% of the bacterial taxa detected in infant’s feces were shared with the corresponding mother’s milk at 5 and 9 months of age, respectively, with Streptococcus, Veillonella and Bifidobacterium spp. among the most frequently shared. The predominant HMOs in feces associated with the infant’s fecal microbiota, and the dominating infant species B. longum ssp. infantis and B. bifidum correlated inversely with HMOs. Our results show that breast milk microbiota changes over time and within a feeding session, likely due to transfer of infant oral bacteria during breastfeeding and suggest that milk-associated bacteria and HMOs direct the assembly of the infant gut microbiota.
AB - Breastfeeding protects against diseases, with potential mechanisms driving this being human milk oligosaccharides (HMOs) and the seeding of milk-associated bacteria in the infant gut. In a cohort of 34 mother–infant dyads we analyzed the microbiota and HMO profiles in breast milk samples and infant’s feces. The microbiota in foremilk and hindmilk samples of breast milk was compositionally similar, however hindmilk had higher bacterial load and absolute abundance of oral-associated bacteria, but a lower absolute abundance of skin-associated Staphylococcus spp. The microbial communities within both milk and infant’s feces changed significantly over the lactation period. On average 33% and 23% of the bacterial taxa detected in infant’s feces were shared with the corresponding mother’s milk at 5 and 9 months of age, respectively, with Streptococcus, Veillonella and Bifidobacterium spp. among the most frequently shared. The predominant HMOs in feces associated with the infant’s fecal microbiota, and the dominating infant species B. longum ssp. infantis and B. bifidum correlated inversely with HMOs. Our results show that breast milk microbiota changes over time and within a feeding session, likely due to transfer of infant oral bacteria during breastfeeding and suggest that milk-associated bacteria and HMOs direct the assembly of the infant gut microbiota.
KW - Faculty of Science
KW - Breastfeeding
KW - Maternal milk microbiota
KW - Human milk oligosaccharides
KW - Infant gut microbiota
U2 - 10.1038/s43705-021-00021-3
DO - 10.1038/s43705-021-00021-3
M3 - Journal article
VL - 1
JO - ISME Communications
JF - ISME Communications
M1 - 21
ER -
ID: 278039791