Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males. / Lund, Michael Taulo; Taudorf, Lærke; Hartmann, Bolette; Helge, Jørn Wulff; Holst, Jens Juul; Dela, Flemming.
In: European Journal of Applied Physiology, Vol. 113, No. 11, 01.11.2013, p. 2737-47.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
AU - Lund, Michael Taulo
AU - Taudorf, Lærke
AU - Hartmann, Bolette
AU - Helge, Jørn Wulff
AU - Holst, Jens Juul
AU - Dela, Flemming
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Postprandial insulin release is lower in healthy aerobically trained (T) compared to untrained (UT) individuals. This may be mediated by a lower release of the two incretin hormones [glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)] in T. The aim of this study was to assess and compare gut hormone response and satiety changes after a liquid meal intake in young, healthy T and UT males. Postprandial gut hormone release and subjective feelings of hunger, satiety, fullness and prospective food consumption were assessed before and frequently for the following 3 h after a 200 ml liquid meal (1,260 kJ and 27, 41 and 32 energy % as protein, carbohydrates and fat, respectively) in ten T and ten UT young, healthy male subjects. The insulin and GIP responses were markedly lower in T than UT and correlated during the first 30 min after the liquid meal. Baseline GLP-1 concentration was higher in T versus UT, but the response in the following 3 h after a liquid meal was similar in T and UT. Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion.
AB - Postprandial insulin release is lower in healthy aerobically trained (T) compared to untrained (UT) individuals. This may be mediated by a lower release of the two incretin hormones [glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)] in T. The aim of this study was to assess and compare gut hormone response and satiety changes after a liquid meal intake in young, healthy T and UT males. Postprandial gut hormone release and subjective feelings of hunger, satiety, fullness and prospective food consumption were assessed before and frequently for the following 3 h after a 200 ml liquid meal (1,260 kJ and 27, 41 and 32 energy % as protein, carbohydrates and fat, respectively) in ten T and ten UT young, healthy male subjects. The insulin and GIP responses were markedly lower in T than UT and correlated during the first 30 min after the liquid meal. Baseline GLP-1 concentration was higher in T versus UT, but the response in the following 3 h after a liquid meal was similar in T and UT. Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion.
KW - Faculty of Health and Medical Sciences
KW - GLP-1
KW - Insulin
KW - Exercise
KW - Training
KW - Incretin
KW - Glucose
U2 - 10.1007/s00421-013-2711-y
DO - 10.1007/s00421-013-2711-y
M3 - Journal article
C2 - 23979179
VL - 113
SP - 2737
EP - 2747
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
SN - 1439-6319
IS - 11
ER -
ID: 107880215