Menopausal transition does not influence skeletal muscle capillary growth in response to cycle training in women
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Menopausal transition does not influence skeletal muscle capillary growth in response to cycle training in women. / Pérez-Gómez, Jorge; Rytter, Nicolai; Mandrup, Camilla M; Egelund, Jon; Stallknecht, Bente; Nyberg, Michael; Hellsten, Ylva.
In: Journal of Applied Physiology, Vol. 131, No. 1, 2021, p. 369-375.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Menopausal transition does not influence skeletal muscle capillary growth in response to cycle training in women
AU - Pérez-Gómez, Jorge
AU - Rytter, Nicolai
AU - Mandrup, Camilla M
AU - Egelund, Jon
AU - Stallknecht, Bente
AU - Nyberg, Michael
AU - Hellsten, Ylva
N1 - CURIS 2021 NEXS 250
PY - 2021
Y1 - 2021
N2 - The influence of the menopausal transition, with a consequent loss of estrogen, on capillary growth in response to exercise training remains unknown. In the present study, we evaluated the effect of a period of intense endurance training on skeletal muscle angiogenesis in late premenopausal and recent postmenopausal women with an age difference of <4 yr. Skeletal musclebiopsies were obtained from the thigh muscle before and after 12 wk of intense aerobic cycle training and analyzed for capillarization, fiber-type distribution, and content of vascular endothelial growth factor (VEGF). At baseline, there was no difference in capillary per fiber ratio (C:F; 1.41 ± 0.22 vs. 1.40 ± 0.30), capillary density (CD; 305 ± 61 vs. 336 ± 52 mm2), muscle fiber area (MFA; 4,889 ± 1,868 vs. 4,195 ± 749), or distribution of muscle fiber type I (47.3% ± 10.1% vs. 49.3% ± 15.1%), between the pre- and postmenopausal women, respectively. There was a main effect of training on the C:F ratio (+9.2% and +12.1%, for the pre- and postmenopausal women, respectively) and the CD (+6.9% and +8.9%, for the pre- and postmenopausal women, respectively). MFA and fiber-type distribution were unaltered by training. Skeletal muscle VEGF protein content was similar between groups at baseline, and there was a main effect of training (+21.1% and +27.2%, for the pre- and postmenopausal women, respectively). In conclusion, the loss of estrogen per se at menopause does not influence the capillary growth response to intense aerobic exercise training.
AB - The influence of the menopausal transition, with a consequent loss of estrogen, on capillary growth in response to exercise training remains unknown. In the present study, we evaluated the effect of a period of intense endurance training on skeletal muscle angiogenesis in late premenopausal and recent postmenopausal women with an age difference of <4 yr. Skeletal musclebiopsies were obtained from the thigh muscle before and after 12 wk of intense aerobic cycle training and analyzed for capillarization, fiber-type distribution, and content of vascular endothelial growth factor (VEGF). At baseline, there was no difference in capillary per fiber ratio (C:F; 1.41 ± 0.22 vs. 1.40 ± 0.30), capillary density (CD; 305 ± 61 vs. 336 ± 52 mm2), muscle fiber area (MFA; 4,889 ± 1,868 vs. 4,195 ± 749), or distribution of muscle fiber type I (47.3% ± 10.1% vs. 49.3% ± 15.1%), between the pre- and postmenopausal women, respectively. There was a main effect of training on the C:F ratio (+9.2% and +12.1%, for the pre- and postmenopausal women, respectively) and the CD (+6.9% and +8.9%, for the pre- and postmenopausal women, respectively). MFA and fiber-type distribution were unaltered by training. Skeletal muscle VEGF protein content was similar between groups at baseline, and there was a main effect of training (+21.1% and +27.2%, for the pre- and postmenopausal women, respectively). In conclusion, the loss of estrogen per se at menopause does not influence the capillary growth response to intense aerobic exercise training.
KW - Faculty of Science
KW - Aerobic exercise
KW - Cardiorespiratory fitness
KW - Endothelial function
KW - High-intensity exercise
KW - Menopause
U2 - 10.1152/japplphysiol.00122.2021
DO - 10.1152/japplphysiol.00122.2021
M3 - Journal article
C2 - 34080923
VL - 131
SP - 369
EP - 375
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 1
ER -
ID: 270664661