Multimodal assessment of precentral anodal TDCS: Individual rise in supplementary motor activity scales with increase in corticospinal excitability
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- Karabanov et al_Frontiers in Human Neuroscience_2021_Vol 15_e639274
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Background: Transcranial direct current stimulation (TDCS) targeting the primary motor hand area (M1-HAND) may induce lasting shifts in corticospinal excitability, but after-effects show substantial inter-individual variability. Functional magnetic resonance imaging (fMRI) can probe after-effects of TDCS on regional neural activity on a whole-brain level.
Objective: Using a double-blinded cross-over design, we investigated whether the individual change in corticospinal excitability after TDCS of M1-HAND is associated with changes in task-related regional activity in cortical motor areas.
Methods: Seventeen healthy volunteers (10 women) received 20 min of real (0.75 mA) or sham TDCS on separate days in randomized order. Real and sham TDCS used the classic bipolar set-up with the anode placed over right M1-HAND. Before and after each TDCS session, we recorded motor evoked potentials (MEP) from the relaxed left first dorsal interosseus muscle after single-pulse transcranial magnetic stimulation(TMS) of left M1-HAND and performed whole-brain fMRI at 3 Tesla while participants completed a visuomotor tracking task with their left hand. We also assessed the difference in MEP latency when applying anterior-posterior and latero-medial TMS pulses to the precentral hand knob (AP-LM MEP latency).
Results: Real TDCS had no consistent aftereffects on mean MEP amplitude, task-related activity or motor performance. Individual changes in MEP amplitude, measured directly after real TDCS showed a positive linear relationship with individual changes in task-related activity in the supplementary motor area and AP-LM MEP latency.
Conclusion: Functional aftereffects of classical bipolar anodal TDCS of M1-HAND on the motor system vary substantially across individuals. Physiological features upstream from the primary motor cortex may determine how anodal TDCS changes corticospinal excitability.
Original language | English |
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Article number | 639274 |
Journal | Frontiers in Human Neuroscience |
Volume | 15 |
Number of pages | 13 |
ISSN | 1662-5161 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Copyright © 2021 Karabanov, Shindo, Shindo, Raffin and Siebner.
- Faculty of Science - Functional magnetic resonance imaging (fMRI), Inter-individual variability, Motor evoked potentials, Primary motor cortex (M1), Supplementary motor area (SMA), Transcranial direct current stimulation (tDCS), Non-invasive brain stimulation, Transcrancial magnetic stimulation (TMS)
Research areas
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