New advanced glycation end products observed in rat urine by untargeted metabolomics after feeding with heat-treated skimmed milk powder
Research output: Contribution to journal › Journal article › Research › peer-review
Scope: Milk powder is commonly consumed throughout the world. However, advanced glycation end products (AGEs) will form in milk powder during thermal processing and long-term storage. We aimed to identify such compounds with potential as new urinary biomarkers of intake of heat-treated skimmed milk powder (HSMP).
Methods and results: A parallel study was performed with different dosages of HSMP as well as hydrolyzed HSMP and untreated skimmed milk powder (SMP) in 36 rats. The 24-h urine samples on day 7 or 8 were collected and profiled by untargeted UPLC-Qtof-MS metabolomics. Statistical analysis revealed 25 metabolites differentiating SMP and HSMP; nineteen of these structures were proposed as lysine- and arginine- derived AGEs, and heterocyclic compounds.
Conclusion: These metabolites may potentially serve as biomarkers of food intake pending further validation to assess intakes of heat-processed dairy foods and thus help to elucidate the effects of HSMP consumption or dietary AGEs on human health.
Original language | English |
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Article number | 2001049 |
Journal | Molecular Nutrition & Food Research |
Volume | 65 |
Issue number | 7 |
Number of pages | 9 |
ISSN | 1613-4125 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
This article is protected by copyright. All rights reserved.
- Faculty of Science - Skimmed milk powder, Metabolomics, Advanced glycation end products, Maillard reaction, Biomarker
Research areas
ID: 256631368