Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium
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Obesity and risk of ovarian cancer subtypes : evidence from the Ovarian Cancer Association Consortium. / Olsen, Catherine M; Nagle, Christina M; Whiteman, David C; Ness, Roberta; Pearce, Celeste Leigh; Pike, Malcolm C; Rossing, Mary Anne; Terry, Kathryn L; Wu, Anna H; Risch, Harvey A; Yu, Herbert; Doherty, Jennifer A; Chang-Claude, Jenny; Hein, Rebecca; Nickels, Stefan; Wang-Gohrke, Shan; Goodman, Marc T; Carney, Michael E; Matsuno, Rayna K; Lurie, Galina; Moysich, Kirsten; Kjaer, Susanne K; Jensen, Allan; Hogdall, Estrid; Goode, Ellen L; Fridley, Brooke L; Vierkant, Robert A; Larson, Melissa C; Schildkraut, Joellen; Hoyo, Cathrine; Moorman, Patricia; Weber, Rachel P; Cramer, Daniel W; Vitonis, Allison F; Bandera, Elisa V; Olson, Sara H; Rodriguez-Rodriguez, Lorna; King, Melony; Brinton, Louise A; Yang, Hannah; Garcia-Closas, Montserrat; Lissowska, Jolanta; Anton-Culver, Hoda; Ziogas, Argyrios; Gayther, Simon A; Ramus, Susan J; Menon, Usha; Gentry-Maharaj, Aleksandra; Webb, Penelope M; Cancer), Australian Cancer Study (Ovarian.
In: Endocrine - Related Cancer, Vol. 20, No. 2, 01.04.2013, p. 251-62.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Obesity and risk of ovarian cancer subtypes
T2 - evidence from the Ovarian Cancer Association Consortium
AU - Olsen, Catherine M
AU - Nagle, Christina M
AU - Whiteman, David C
AU - Ness, Roberta
AU - Pearce, Celeste Leigh
AU - Pike, Malcolm C
AU - Rossing, Mary Anne
AU - Terry, Kathryn L
AU - Wu, Anna H
AU - Risch, Harvey A
AU - Yu, Herbert
AU - Doherty, Jennifer A
AU - Chang-Claude, Jenny
AU - Hein, Rebecca
AU - Nickels, Stefan
AU - Wang-Gohrke, Shan
AU - Goodman, Marc T
AU - Carney, Michael E
AU - Matsuno, Rayna K
AU - Lurie, Galina
AU - Moysich, Kirsten
AU - Kjaer, Susanne K
AU - Jensen, Allan
AU - Hogdall, Estrid
AU - Goode, Ellen L
AU - Fridley, Brooke L
AU - Vierkant, Robert A
AU - Larson, Melissa C
AU - Schildkraut, Joellen
AU - Hoyo, Cathrine
AU - Moorman, Patricia
AU - Weber, Rachel P
AU - Cramer, Daniel W
AU - Vitonis, Allison F
AU - Bandera, Elisa V
AU - Olson, Sara H
AU - Rodriguez-Rodriguez, Lorna
AU - King, Melony
AU - Brinton, Louise A
AU - Yang, Hannah
AU - Garcia-Closas, Montserrat
AU - Lissowska, Jolanta
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Gayther, Simon A
AU - Ramus, Susan J
AU - Menon, Usha
AU - Gentry-Maharaj, Aleksandra
AU - Webb, Penelope M
AU - Cancer), Australian Cancer Study (Ovarian
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and classification of ovarian histology has improved in the last decade, we sought to examine the association in a pooled analysis of recent studies participating in the Ovarian Cancer Association Consortium. We evaluated the association between BMI (recent, maximum and in young adulthood) and ovarian cancer risk using original data from 15 case–control studies (13 548 cases and 17 913 controls). We combined study-specific adjusted odds ratios (ORs) using a random-effects model. We further examined the associations by histological subtype, menopausal status and post-menopausal hormone use. High BMI (all time-points) was associated with increased risk. This was most pronounced for borderline serous (recent BMI: pooled OR=1.24 per 5 kg/m2; 95% CI 1.18–1.30), invasive endometrioid (1.17; 1.11–1.23) and invasive mucinous (1.19; 1.06–1.32) tumours. There was no association with serous invasive cancer overall (0.98; 0.94–1.02), but increased risks for low-grade serous invasive tumours (1.13, 1.03–1.25) and in pre-menopausal women (1.11; 1.04–1.18). Among post-menopausal women, the associations did not differ between hormone replacement therapy users and non-users. Whilst obesity appears to increase risk of the less common histological subtypes of ovarian cancer, it does not increase risk of high-grade invasive serous cancers, and reducing BMI is therefore unlikely to prevent the majority of ovarian cancer deaths. Other modifiable factors must be identified to control this disease.
AB - Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and classification of ovarian histology has improved in the last decade, we sought to examine the association in a pooled analysis of recent studies participating in the Ovarian Cancer Association Consortium. We evaluated the association between BMI (recent, maximum and in young adulthood) and ovarian cancer risk using original data from 15 case–control studies (13 548 cases and 17 913 controls). We combined study-specific adjusted odds ratios (ORs) using a random-effects model. We further examined the associations by histological subtype, menopausal status and post-menopausal hormone use. High BMI (all time-points) was associated with increased risk. This was most pronounced for borderline serous (recent BMI: pooled OR=1.24 per 5 kg/m2; 95% CI 1.18–1.30), invasive endometrioid (1.17; 1.11–1.23) and invasive mucinous (1.19; 1.06–1.32) tumours. There was no association with serous invasive cancer overall (0.98; 0.94–1.02), but increased risks for low-grade serous invasive tumours (1.13, 1.03–1.25) and in pre-menopausal women (1.11; 1.04–1.18). Among post-menopausal women, the associations did not differ between hormone replacement therapy users and non-users. Whilst obesity appears to increase risk of the less common histological subtypes of ovarian cancer, it does not increase risk of high-grade invasive serous cancers, and reducing BMI is therefore unlikely to prevent the majority of ovarian cancer deaths. Other modifiable factors must be identified to control this disease.
KW - Faculty of Health and Medical Sciences
KW - ovarian cancer
KW - obesity
KW - BMI
U2 - 10.1530/ERC-12-0395
DO - 10.1530/ERC-12-0395
M3 - Journal article
C2 - 23404857
VL - 20
SP - 251
EP - 262
JO - Endocrine - Related Cancer
JF - Endocrine - Related Cancer
SN - 1351-0088
IS - 2
ER -
ID: 117436208