Partial agonists and subunit selectivity at NMDA receptors
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Partial agonists and subunit selectivity at NMDA receptors. / Risgaard, Rune; Hansen, Kasper Bø; Clausen, Rasmus Prætorius.
In: Chemistry: A European Journal, Vol. 16, No. 47, 17.12.2010, p. 13910-13918.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Partial agonists and subunit selectivity at NMDA receptors
AU - Risgaard, Rune
AU - Hansen, Kasper Bø
AU - Clausen, Rasmus Prætorius
N1 - Keywords: agonists, glutamate, ligand design, receptors, subunit selectivity
PY - 2010/12/17
Y1 - 2010/12/17
N2 - Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.
AB - Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1002/chem.201001366
DO - 10.1002/chem.201001366
M3 - Review
C2 - 20945316
VL - 16
SP - 13910
EP - 13918
JO - Chemistry: A European Journal
JF - Chemistry: A European Journal
SN - 0947-6539
IS - 47
ER -
ID: 33701222