Tendon blood flow, angiogenesis, and tendinopathy pathogenesis
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Tendon blood flow, angiogenesis, and tendinopathy pathogenesis. / Merkel, Max Flemming Ravn; Hellsten, Ylva; Magnusson, Stig Peter; Kjær, Michael.
In: Translational Sports Medicine, Vol. 4, No. 6, 2021, p. 756-771.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Tendon blood flow, angiogenesis, and tendinopathy pathogenesis
AU - Merkel, Max Flemming Ravn
AU - Hellsten, Ylva
AU - Magnusson, Stig Peter
AU - Kjær, Michael
N1 - CURIS 2021 NEXS 301
PY - 2021
Y1 - 2021
N2 - Physical exercise results in a duration and intensity-dependent vascular response in healthy human tendon. In overused (tendinopathy) and damagedtendon, angiogenic pathways are activated and neovascularization is observed.Whereas no direct relationship exists between the amount of neovessels and degree of tendinopathy symptoms, almost all tendinopathic patients have elevated neovascularization and tendon blood flow, as assessed by Doppler ultrasound methodology. The enhanced flow in tendinopathy can be successfully abolished by heavy resistance training. Already in the early time-phase of tendinopathy (<3 months), neovascularization in the tendon exists but the causal sequence of vascular, metabolic, nociceptive, and matrix tissue changes in tendon pathology is not fully understood. Nevertheless, existing evidences point at neovascularization being an important component of pathogenesis and may occur already before the development of clinical symptoms in tendinopathy.
AB - Physical exercise results in a duration and intensity-dependent vascular response in healthy human tendon. In overused (tendinopathy) and damagedtendon, angiogenic pathways are activated and neovascularization is observed.Whereas no direct relationship exists between the amount of neovessels and degree of tendinopathy symptoms, almost all tendinopathic patients have elevated neovascularization and tendon blood flow, as assessed by Doppler ultrasound methodology. The enhanced flow in tendinopathy can be successfully abolished by heavy resistance training. Already in the early time-phase of tendinopathy (<3 months), neovascularization in the tendon exists but the causal sequence of vascular, metabolic, nociceptive, and matrix tissue changes in tendon pathology is not fully understood. Nevertheless, existing evidences point at neovascularization being an important component of pathogenesis and may occur already before the development of clinical symptoms in tendinopathy.
KW - Faculty of Science
KW - Angiogenesis
KW - Blood flow
KW - Neovascularization
KW - Overuse
KW - Tendinopathy
KW - Tendon
U2 - 10.1002/tsm2.280
DO - 10.1002/tsm2.280
M3 - Review
VL - 4
SP - 756
EP - 771
JO - Translational Sports Medicine
JF - Translational Sports Medicine
SN - 2573-8488
IS - 6
ER -
ID: 280607714