Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. / Cortes, Adrian; Hadler, Johanna; Pointon, Jenny P.; Robinson, Philip C.; Karaderi, Tugce; Leo, Paul; Cremin, Katie; Pryce, Karena; Harris, Jessica; Lee, Seunghun; Joo, Kyung Bin; Shim, Seung Cheol; Weisman, Michael; Ward, Michael; Zhou, Xiaodong; Garchon, Henri Jean; Chiocchia, Gilles; Nossent, Johannes; Lie, Benedicte A.; Førre, Øystein; Tuomilehto, Jaakko; Laiho, Kari; Jiang, Lei; Liu, Yu; Wu, Xin; Bradbury, Linda A.; Elewaut, Dirk; Burgos-Vargas, Ruben; Stebbings, Simon; Appleton, Louise; Farrah, Claire; Lau, Jonathan; Kenna, Tony J.; Haroon, Nigil; Ferreira, Manuel A.; Yang, Jian; Mulero, Juan; Fernandez-Sueiro, Jose Luis; Gonzalez-Gay, Miguel A.; Lopez-Larrea, Carlos; Deloukas, Panos; Donnelly, Peter; Bowness, Paul; Gafney, Karl; Gaston, Hill; Gladman, Dafna D.; Rahman, Proton; Maksymowych, Walter P.; Xu, Huji; Crusius, J. Bart A.

In: Nature Genetics, Vol. 45, No. 7, 01.07.2013, p. 730-738.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cortes, A, Hadler, J, Pointon, JP, Robinson, PC, Karaderi, T, Leo, P, Cremin, K, Pryce, K, Harris, J, Lee, S, Joo, KB, Shim, SC, Weisman, M, Ward, M, Zhou, X, Garchon, HJ, Chiocchia, G, Nossent, J, Lie, BA, Førre, Ø, Tuomilehto, J, Laiho, K, Jiang, L, Liu, Y, Wu, X, Bradbury, LA, Elewaut, D, Burgos-Vargas, R, Stebbings, S, Appleton, L, Farrah, C, Lau, J, Kenna, TJ, Haroon, N, Ferreira, MA, Yang, J, Mulero, J, Fernandez-Sueiro, JL, Gonzalez-Gay, MA, Lopez-Larrea, C, Deloukas, P, Donnelly, P, Bowness, P, Gafney, K, Gaston, H, Gladman, DD, Rahman, P, Maksymowych, WP, Xu, H & Crusius, JBA 2013, 'Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci', Nature Genetics, vol. 45, no. 7, pp. 730-738. https://doi.org/10.1038/ng.2667

APA

Cortes, A., Hadler, J., Pointon, J. P., Robinson, P. C., Karaderi, T., Leo, P., Cremin, K., Pryce, K., Harris, J., Lee, S., Joo, K. B., Shim, S. C., Weisman, M., Ward, M., Zhou, X., Garchon, H. J., Chiocchia, G., Nossent, J., Lie, B. A., ... Crusius, J. B. A. (2013). Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nature Genetics, 45(7), 730-738. https://doi.org/10.1038/ng.2667

Vancouver

Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T, Leo P et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nature Genetics. 2013 Jul 1;45(7):730-738. https://doi.org/10.1038/ng.2667

Author

Cortes, Adrian ; Hadler, Johanna ; Pointon, Jenny P. ; Robinson, Philip C. ; Karaderi, Tugce ; Leo, Paul ; Cremin, Katie ; Pryce, Karena ; Harris, Jessica ; Lee, Seunghun ; Joo, Kyung Bin ; Shim, Seung Cheol ; Weisman, Michael ; Ward, Michael ; Zhou, Xiaodong ; Garchon, Henri Jean ; Chiocchia, Gilles ; Nossent, Johannes ; Lie, Benedicte A. ; Førre, Øystein ; Tuomilehto, Jaakko ; Laiho, Kari ; Jiang, Lei ; Liu, Yu ; Wu, Xin ; Bradbury, Linda A. ; Elewaut, Dirk ; Burgos-Vargas, Ruben ; Stebbings, Simon ; Appleton, Louise ; Farrah, Claire ; Lau, Jonathan ; Kenna, Tony J. ; Haroon, Nigil ; Ferreira, Manuel A. ; Yang, Jian ; Mulero, Juan ; Fernandez-Sueiro, Jose Luis ; Gonzalez-Gay, Miguel A. ; Lopez-Larrea, Carlos ; Deloukas, Panos ; Donnelly, Peter ; Bowness, Paul ; Gafney, Karl ; Gaston, Hill ; Gladman, Dafna D. ; Rahman, Proton ; Maksymowych, Walter P. ; Xu, Huji ; Crusius, J. Bart A. / Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. In: Nature Genetics. 2013 ; Vol. 45, No. 7. pp. 730-738.

Bibtex

@article{1fa3d25d23004e90b087dd1dd1b9a1f2,
title = "Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci",
abstract = "Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.",
author = "Adrian Cortes and Johanna Hadler and Pointon, {Jenny P.} and Robinson, {Philip C.} and Tugce Karaderi and Paul Leo and Katie Cremin and Karena Pryce and Jessica Harris and Seunghun Lee and Joo, {Kyung Bin} and Shim, {Seung Cheol} and Michael Weisman and Michael Ward and Xiaodong Zhou and Garchon, {Henri Jean} and Gilles Chiocchia and Johannes Nossent and Lie, {Benedicte A.} and {\O}ystein F{\o}rre and Jaakko Tuomilehto and Kari Laiho and Lei Jiang and Yu Liu and Xin Wu and Bradbury, {Linda A.} and Dirk Elewaut and Ruben Burgos-Vargas and Simon Stebbings and Louise Appleton and Claire Farrah and Jonathan Lau and Kenna, {Tony J.} and Nigil Haroon and Ferreira, {Manuel A.} and Jian Yang and Juan Mulero and Fernandez-Sueiro, {Jose Luis} and Gonzalez-Gay, {Miguel A.} and Carlos Lopez-Larrea and Panos Deloukas and Peter Donnelly and Paul Bowness and Karl Gafney and Hill Gaston and Gladman, {Dafna D.} and Proton Rahman and Maksymowych, {Walter P.} and Huji Xu and Crusius, {J. Bart A.}",
year = "2013",
month = jul,
day = "1",
doi = "10.1038/ng.2667",
language = "English",
volume = "45",
pages = "730--738",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "7",

}

RIS

TY - JOUR

T1 - Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

AU - Cortes, Adrian

AU - Hadler, Johanna

AU - Pointon, Jenny P.

AU - Robinson, Philip C.

AU - Karaderi, Tugce

AU - Leo, Paul

AU - Cremin, Katie

AU - Pryce, Karena

AU - Harris, Jessica

AU - Lee, Seunghun

AU - Joo, Kyung Bin

AU - Shim, Seung Cheol

AU - Weisman, Michael

AU - Ward, Michael

AU - Zhou, Xiaodong

AU - Garchon, Henri Jean

AU - Chiocchia, Gilles

AU - Nossent, Johannes

AU - Lie, Benedicte A.

AU - Førre, Øystein

AU - Tuomilehto, Jaakko

AU - Laiho, Kari

AU - Jiang, Lei

AU - Liu, Yu

AU - Wu, Xin

AU - Bradbury, Linda A.

AU - Elewaut, Dirk

AU - Burgos-Vargas, Ruben

AU - Stebbings, Simon

AU - Appleton, Louise

AU - Farrah, Claire

AU - Lau, Jonathan

AU - Kenna, Tony J.

AU - Haroon, Nigil

AU - Ferreira, Manuel A.

AU - Yang, Jian

AU - Mulero, Juan

AU - Fernandez-Sueiro, Jose Luis

AU - Gonzalez-Gay, Miguel A.

AU - Lopez-Larrea, Carlos

AU - Deloukas, Panos

AU - Donnelly, Peter

AU - Bowness, Paul

AU - Gafney, Karl

AU - Gaston, Hill

AU - Gladman, Dafna D.

AU - Rahman, Proton

AU - Maksymowych, Walter P.

AU - Xu, Huji

AU - Crusius, J. Bart A.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.

AB - Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.

UR - http://www.scopus.com/inward/record.url?scp=84879691837&partnerID=8YFLogxK

U2 - 10.1038/ng.2667

DO - 10.1038/ng.2667

M3 - Journal article

C2 - 23749187

AN - SCOPUS:84879691837

VL - 45

SP - 730

EP - 738

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 7

ER -

ID: 226396293