Moderate alcohol consumption and lipoprotein subfractions: A systematic review of intervention and observational studies
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Moderate alcohol consumption and lipoprotein subfractions: A systematic review of intervention and observational studies. / Wilkens, Trine; Tranæs, Kaare; Eriksen, Jane Nygaard; Dragsted, Lars Ove.
In: Nutrition Reviews, Vol. 80, No. 5, 2022, p. 1311-1339.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Moderate alcohol consumption and lipoprotein subfractions: A systematic review of intervention and observational studies
AU - Wilkens, Trine
AU - Tranæs, Kaare
AU - Eriksen, Jane Nygaard
AU - Dragsted, Lars Ove
N1 - CURIS 2022 NEXS 010
PY - 2022
Y1 - 2022
N2 - Context: Moderate alcohol consumption is associated with decreased risk of cardiovascular disease (CVD) and improvement in cardiovascular risk markers, including lipoproteins and lipoprotein subfractions. Objective: To systematically review the relationship between moderate alcohol intake, lipoprotein subfractions, and related mechanisms. Data sources: Following PRISMA, all human and ex vivo studies with an alcohol intake up to 60 g/d were included from 8 databases. Data extraction: A total of 17 478 studies were screened, and data were extracted from 37 intervention and 77 observational studies. Results: Alcohol intake was positively associated with all HDL subfractions. A few studies found lower levels of small LDLs, increased average LDL particle size, and nonlinear relationships to apolipoprotein B–containing lipoproteins. Cholesterol efflux capacity and paraoxonase activity were consistently increased. Several studies had unclear or high risk of bias, and heterogeneous laboratory methods restricted comparability between studies.Conclusions: Up to 60 g/d alcohol can cause changes in lipoprotein subfractionsand related mechanisms that could influence cardiovascular health.Systematic Review Registration: PROSPERO registration no. 98955
AB - Context: Moderate alcohol consumption is associated with decreased risk of cardiovascular disease (CVD) and improvement in cardiovascular risk markers, including lipoproteins and lipoprotein subfractions. Objective: To systematically review the relationship between moderate alcohol intake, lipoprotein subfractions, and related mechanisms. Data sources: Following PRISMA, all human and ex vivo studies with an alcohol intake up to 60 g/d were included from 8 databases. Data extraction: A total of 17 478 studies were screened, and data were extracted from 37 intervention and 77 observational studies. Results: Alcohol intake was positively associated with all HDL subfractions. A few studies found lower levels of small LDLs, increased average LDL particle size, and nonlinear relationships to apolipoprotein B–containing lipoproteins. Cholesterol efflux capacity and paraoxonase activity were consistently increased. Several studies had unclear or high risk of bias, and heterogeneous laboratory methods restricted comparability between studies.Conclusions: Up to 60 g/d alcohol can cause changes in lipoprotein subfractionsand related mechanisms that could influence cardiovascular health.Systematic Review Registration: PROSPERO registration no. 98955
KW - Faculty of Science
KW - apoB-containing lipoproteins
KW - Cardiovascular disease
KW - Cholesterol efflux capacity
KW - High-density lipoprotein cholesterol
KW - paraoxonase
U2 - 10.1093/nutrit/nuab102
DO - 10.1093/nutrit/nuab102
M3 - Review
C2 - 34957513
VL - 80
SP - 1311
EP - 1339
JO - Nutrition Reviews
JF - Nutrition Reviews
SN - 0029-6643
IS - 5
ER -
ID: 282743103