Physical fitness and frailty in males after allogeneic hematopoietic stem cell transplantation in childhood: A long-term follow-up study
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Physical fitness and frailty in males after allogeneic hematopoietic stem cell transplantation in childhood: A long-term follow-up study. / Suominen, Anu; Haavisto, Anu; Mathiesen, Sidsel; Mejdahl Nielsen, Malene; Lähteenmäki, Päivi M; Sørensen, Kaspar; Ifversen, Marianne; Mølgaard, Christian; Juul, Anders; Müller, Klaus; Jahnukainen, Kirsi.
In: Cancers, Vol. 14, No. 14, 3310, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Physical fitness and frailty in males after allogeneic hematopoietic stem cell transplantation in childhood: A long-term follow-up study
AU - Suominen, Anu
AU - Haavisto, Anu
AU - Mathiesen, Sidsel
AU - Mejdahl Nielsen, Malene
AU - Lähteenmäki, Päivi M
AU - Sørensen, Kaspar
AU - Ifversen, Marianne
AU - Mølgaard, Christian
AU - Juul, Anders
AU - Müller, Klaus
AU - Jahnukainen, Kirsi
N1 - CURIS 2022 NEXS 182
PY - 2022
Y1 - 2022
N2 - Purpose and methods: To analyze physical fitness, physical activity and the prevalence of frailty in male long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation (HSCT). We performed a Nordic two-center study of 98 male survivors (mean age 28.7 years, range 18.5-47.0) treated with pediatric allogeneic hematopoietic stem cell transplantation (HSCT) 1980-2010 in Denmark or Finland. physical fitness was evaluated by the dominant hand grip-strength, timed up-and-go, sit-to-stand, gait speed and two-minute walk tests.Results: Survivors presented significantly lower muscle strength and muscle endurance in the dominant hand-grip strength (median Z-score -0.7, range -4.3-3.9) and sit-to-stand tests (median Z-score -1.5, range -3.5-2.5) compared to age and sex matched normative values of the tests. However, mobility and gait speed were not affected on a group level. The prevalence of frailty (pre-frail 20% or frail 10%) was high among the survivors. In multiple regression analysis, chronic graft-versus-host disease, shorter stature, higher body fat mass and hazardous drinking predicted prefrail/frail status. Common cardiovascular risk factors, such as increased levels of serum triglycerides, higher resting heart rate and diastolic blood pressure, were associated with lower physical fitness.Conclusion: Low muscle strength and a high incidence of frailty were observed in survivors of pediatric HSCT. There is a predominant risk of cardiovascular and metabolic diseases in the long-term.
AB - Purpose and methods: To analyze physical fitness, physical activity and the prevalence of frailty in male long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation (HSCT). We performed a Nordic two-center study of 98 male survivors (mean age 28.7 years, range 18.5-47.0) treated with pediatric allogeneic hematopoietic stem cell transplantation (HSCT) 1980-2010 in Denmark or Finland. physical fitness was evaluated by the dominant hand grip-strength, timed up-and-go, sit-to-stand, gait speed and two-minute walk tests.Results: Survivors presented significantly lower muscle strength and muscle endurance in the dominant hand-grip strength (median Z-score -0.7, range -4.3-3.9) and sit-to-stand tests (median Z-score -1.5, range -3.5-2.5) compared to age and sex matched normative values of the tests. However, mobility and gait speed were not affected on a group level. The prevalence of frailty (pre-frail 20% or frail 10%) was high among the survivors. In multiple regression analysis, chronic graft-versus-host disease, shorter stature, higher body fat mass and hazardous drinking predicted prefrail/frail status. Common cardiovascular risk factors, such as increased levels of serum triglycerides, higher resting heart rate and diastolic blood pressure, were associated with lower physical fitness.Conclusion: Low muscle strength and a high incidence of frailty were observed in survivors of pediatric HSCT. There is a predominant risk of cardiovascular and metabolic diseases in the long-term.
KW - Faculty of Science
KW - Physical fitness
KW - GvHD
KW - Frailty
KW - Aging
KW - Pediatric hematopoietic stem cell transplantation
KW - Late effects
U2 - 10.3390/cancers14143310
DO - 10.3390/cancers14143310
M3 - Journal article
C2 - 35884371
VL - 14
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 14
M1 - 3310
ER -
ID: 315269603