Physical fitness and frailty in males after allogeneic hematopoietic stem cell transplantation in childhood: A long-term follow-up study
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- Suominen et al_Cancers_2022_Vol 14(14)_e3310
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Purpose and methods: To analyze physical fitness, physical activity and the prevalence of frailty in male long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation (HSCT). We performed a Nordic two-center study of 98 male survivors (mean age 28.7 years, range 18.5-47.0) treated with pediatric allogeneic hematopoietic stem cell transplantation (HSCT) 1980-2010 in Denmark or Finland. physical fitness was evaluated by the dominant hand grip-strength, timed up-and-go, sit-to-stand, gait speed and two-minute walk tests.
Results: Survivors presented significantly lower muscle strength and muscle endurance in the dominant hand-grip strength (median Z-score -0.7, range -4.3-3.9) and sit-to-stand tests (median Z-score -1.5, range -3.5-2.5) compared to age and sex matched normative values of the tests. However, mobility and gait speed were not affected on a group level. The prevalence of frailty (pre-frail 20% or frail 10%) was high among the survivors. In multiple regression analysis, chronic graft-versus-host disease, shorter stature, higher body fat mass and hazardous drinking predicted prefrail/frail status. Common cardiovascular risk factors, such as increased levels of serum triglycerides, higher resting heart rate and diastolic blood pressure, were associated with lower physical fitness.
Conclusion: Low muscle strength and a high incidence of frailty were observed in survivors of pediatric HSCT. There is a predominant risk of cardiovascular and metabolic diseases in the long-term.
Original language | English |
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Article number | 3310 |
Journal | Cancers |
Volume | 14 |
Issue number | 14 |
Number of pages | 12 |
ISSN | 2072-6694 |
DOIs | |
Publication status | Published - 2022 |
- Faculty of Science - Physical fitness, GvHD, Frailty, Aging, Pediatric hematopoietic stem cell transplantation, Late effects
Research areas
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