Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study
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Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study. / Drummen, Mathijs; Tischmann, Lea; Gatta-Cherifi, Blandine; Cota, Daniela; Matias, Isabelle; Raben, Anne; Adam, Tanja; Westerterp-Plantenga, Margriet.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 105, No. 7, 2020, p. e2511-e2520.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study
AU - Drummen, Mathijs
AU - Tischmann, Lea
AU - Gatta-Cherifi, Blandine
AU - Cota, Daniela
AU - Matias, Isabelle
AU - Raben, Anne
AU - Adam, Tanja
AU - Westerterp-Plantenga, Margriet
N1 - © Endocrine Society 2020.
PY - 2020
Y1 - 2020
N2 - Context: Endocannabinoids are suggested to play a role in energy balance regulation.Objective: We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the post-obese phase with pre-diabetes.Design and participants: Participants (n=38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% energy from P:C:F) for 48 hours in a respiration chamber.Main outcome measures: Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed.Results: Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to BMI (AEA) or body-fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. AUC of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body-fat% (P < 0.05). The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs. the MP group.Conclusions: In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, while the endocannabinoid AEA, and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure over the day.
AB - Context: Endocannabinoids are suggested to play a role in energy balance regulation.Objective: We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the post-obese phase with pre-diabetes.Design and participants: Participants (n=38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% energy from P:C:F) for 48 hours in a respiration chamber.Main outcome measures: Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed.Results: Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to BMI (AEA) or body-fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. AUC of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body-fat% (P < 0.05). The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs. the MP group.Conclusions: In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, while the endocannabinoid AEA, and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure over the day.
KW - Faculty of Science
KW - Endocannabinoids
KW - Energy balance
KW - Adiposisty
KW - Protein
U2 - 10.1210/clinem/dgaa193
DO - 10.1210/clinem/dgaa193
M3 - Journal article
C2 - 32333763
VL - 105
SP - e2511-e2520
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 7
ER -
ID: 240979041