Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men
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Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men. / Garcia, V P; Mattos, J D; Mentzinger, J; Leite, P E C; Rocha, H N M; Campos, M O; Rocha, M P; Mansur, D E; Secher, Niels H.; Nóbrega, A C L; Fernandes, I A; Rocha, N G.
In: Brazilian Journal of Medical and Biological Research, Vol. 55, e12110, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men
AU - Garcia, V P
AU - Mattos, J D
AU - Mentzinger, J
AU - Leite, P E C
AU - Rocha, H N M
AU - Campos, M O
AU - Rocha, M P
AU - Mansur, D E
AU - Secher, Niels H.
AU - Nóbrega, A C L
AU - Fernandes, I A
AU - Rocha, N G
N1 - (Ekstern)
PY - 2022
Y1 - 2022
N2 - In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrixmetalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.
AB - In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrixmetalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.
KW - Faculty of Science
KW - Endothelium
KW - Hyperoxia
KW - ICAM-1
KW - Metalloproteinase-9
KW - Vascular remodeling
UR - https://doi.org/10.1590/1414-431x2022e12110
U2 - 10.1590/1414-431x2022e12110
DO - 10.1590/1414-431x2022e12110
M3 - Journal article
VL - 55
JO - Brazilian Journal of Medical and Biological Research
JF - Brazilian Journal of Medical and Biological Research
SN - 0100-879X
M1 - e12110
ER -
ID: 310835231