Short-term supplementation with fermented red clover extract reduces vascular inflammation in early post-menopausal women
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Short-term supplementation with fermented red clover extract reduces vascular inflammation in early post-menopausal women. / Wickham, Kate Aiko; Nørregaard, Line Boel; Oxfeldt, Mikkel; Cheung, Stephen S; Gliemann, Lasse; Hansen, Mette; Hellsten, Ylva.
In: Frontiers in Cardiovascular Medicine, Vol. 9, 826959, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Short-term supplementation with fermented red clover extract reduces vascular inflammation in early post-menopausal women
AU - Wickham, Kate Aiko
AU - Nørregaard, Line Boel
AU - Oxfeldt, Mikkel
AU - Cheung, Stephen S
AU - Gliemann, Lasse
AU - Hansen, Mette
AU - Hellsten, Ylva
N1 - Copyright © 2022 Wickham, Nørregaard, Oxfeldt, Cheung, Gliemann, Hansen and Hellsten.
PY - 2022
Y1 - 2022
N2 - The decline in estrogen at menopause poses a critical challenge to cardiovascular and metabolic health. Recently, a growing interest in the role of phytoestrogens, with a particular focus on isoflavones, has emerged as they can bind to estrogen receptors and may mimic the roles of endogenous estrogen. Fermented red clover extract (RC) contains isoflavones with superior bioavailability compared to non-fermented isoflavones, however little is known regarding the impact of isoflavones on cardiovascular and metabolic health. We assessed markers of vascular health in plasma and skeletal muscle samples obtained from healthy but sedentary early post-menopausal women (n = 10; 54 ± 4 years) following 2 weeks of twice daily treatment with placebo (PLA) or RC (60 mg isoflavones per day). The two interventions were administered using a randomized, double-blind, crossover design with a two-week washout period. Plasma samples were utilized for assessment of markers of vascular inflammation. There was a statistically significant reduction (~5.4%) in vascular cell adhesion molecule 1 (VCAM-1) following 2 weeks of RC supplementation compared to PLA (p = 0.03). In contrast, there was no effect of RC supplementation compared to PLA on skeletal muscle estrogen receptor content and enzymes related to vascular function, and angiogenesis. Supplementation with RC reduces vascular inflammation in early post-menopausal women and future studies should address the long-term impact of daily supplementation with RC after menopause.
AB - The decline in estrogen at menopause poses a critical challenge to cardiovascular and metabolic health. Recently, a growing interest in the role of phytoestrogens, with a particular focus on isoflavones, has emerged as they can bind to estrogen receptors and may mimic the roles of endogenous estrogen. Fermented red clover extract (RC) contains isoflavones with superior bioavailability compared to non-fermented isoflavones, however little is known regarding the impact of isoflavones on cardiovascular and metabolic health. We assessed markers of vascular health in plasma and skeletal muscle samples obtained from healthy but sedentary early post-menopausal women (n = 10; 54 ± 4 years) following 2 weeks of twice daily treatment with placebo (PLA) or RC (60 mg isoflavones per day). The two interventions were administered using a randomized, double-blind, crossover design with a two-week washout period. Plasma samples were utilized for assessment of markers of vascular inflammation. There was a statistically significant reduction (~5.4%) in vascular cell adhesion molecule 1 (VCAM-1) following 2 weeks of RC supplementation compared to PLA (p = 0.03). In contrast, there was no effect of RC supplementation compared to PLA on skeletal muscle estrogen receptor content and enzymes related to vascular function, and angiogenesis. Supplementation with RC reduces vascular inflammation in early post-menopausal women and future studies should address the long-term impact of daily supplementation with RC after menopause.
KW - Faculty of Science
KW - Fermented red clover
KW - Phytoestrogen
KW - Isoflavones
KW - Post-menopausal women
KW - Supplementation
KW - Cardiovascular health
KW - Vascular inflammation
KW - Skeletal muscle microcirculation
U2 - 10.3389/fcvm.2022.826959
DO - 10.3389/fcvm.2022.826959
M3 - Journal article
C2 - 35224058
VL - 9
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
SN - 2297-055X
M1 - 826959
ER -
ID: 298481089