The importance of fatty acids as nutrients during post-exercise recovery
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The importance of fatty acids as nutrients during post-exercise recovery. / Lundsgaard, Annemarie; Fritzen, Andreas Mæchel; Kiens, Bente.
In: Nutrients, Vol. 12, No. 2, 280, 2020.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The importance of fatty acids as nutrients during post-exercise recovery
AU - Lundsgaard, Annemarie
AU - Fritzen, Andreas Mæchel
AU - Kiens, Bente
N1 - CURIS 2020 NEXS 044
PY - 2020
Y1 - 2020
N2 - It is well recognized that whole-body fatty acid (FA) oxidation remains increased for several hours following aerobic endurance exercise, even despite carbohydrate intake. However, the mechanisms involved herein have hitherto not been subject to a thorough evaluation. In immediate and early recovery (0-4 h), plasma FA availability is high, which seems mainly to be a result of hormonal factors and increased adipose tissue blood flow. The increased circulating availability of adipose-derived FA, coupled with FA from lipoprotein lipase (LPL)-derived very-low density lipoprotein (VLDL)-triacylglycerol (TG) hydrolysis in skeletal muscle capillaries and hydrolysis of TG within the muscle together act as substrates for the increased mitochondrial FA oxidation post-exercise. Within the skeletal muscle cells, increased reliance on FA oxidation likely results from enhanced FA uptake into the mitochondria through the carnitine palmitoyltransferase (CPT) 1 reaction, and concomitant AMP-activated protein kinase (AMPK)-mediated pyruvate dehydrogenase (PDH) inhibition of glucose oxidation. Together this allows glucose taken up by the skeletal muscles to be directed towards the resynthesis of glycogen. Besides being oxidized, FAs also seem to be crucial signaling molecules for peroxisome proliferator-activated receptor (PPAR) signaling post-exercise, and thus for induction of the exercise-induced FA oxidative gene adaptation program in skeletal muscle following exercise. Collectively, a high FA turnover in recovery seems essential to regain whole-body substrate homeostasis.
AB - It is well recognized that whole-body fatty acid (FA) oxidation remains increased for several hours following aerobic endurance exercise, even despite carbohydrate intake. However, the mechanisms involved herein have hitherto not been subject to a thorough evaluation. In immediate and early recovery (0-4 h), plasma FA availability is high, which seems mainly to be a result of hormonal factors and increased adipose tissue blood flow. The increased circulating availability of adipose-derived FA, coupled with FA from lipoprotein lipase (LPL)-derived very-low density lipoprotein (VLDL)-triacylglycerol (TG) hydrolysis in skeletal muscle capillaries and hydrolysis of TG within the muscle together act as substrates for the increased mitochondrial FA oxidation post-exercise. Within the skeletal muscle cells, increased reliance on FA oxidation likely results from enhanced FA uptake into the mitochondria through the carnitine palmitoyltransferase (CPT) 1 reaction, and concomitant AMP-activated protein kinase (AMPK)-mediated pyruvate dehydrogenase (PDH) inhibition of glucose oxidation. Together this allows glucose taken up by the skeletal muscles to be directed towards the resynthesis of glycogen. Besides being oxidized, FAs also seem to be crucial signaling molecules for peroxisome proliferator-activated receptor (PPAR) signaling post-exercise, and thus for induction of the exercise-induced FA oxidative gene adaptation program in skeletal muscle following exercise. Collectively, a high FA turnover in recovery seems essential to regain whole-body substrate homeostasis.
KW - Faculty of Science
KW - Post-exercise recovery
KW - Fatty acid oxidation
KW - Skeletal muscle
KW - Lipid metabolism
KW - Molecular mechanism
KW - Adipose tissue lipolysis
KW - AMP-activated protein kinase (AMPK)
KW - Pyruvate dehydrogenase (PDH)
KW - Carnitine palmitoyltransferase I (CPT1)
KW - Lipoprotein lipase (LPL)
U2 - 10.3390/nu12020280
DO - 10.3390/nu12020280
M3 - Review
C2 - 31973165
VL - 12
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 280
ER -
ID: 237511361