The relationship between circulating acetate and human insulin resistance before and after weight loss in the DiOGenes study
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The relationship between circulating acetate and human insulin resistance before and after weight loss in the DiOGenes study. / González Hernández, Manuel A; Canfora, Emanuel E; Pasmans, Kenneth; Astrup, Arne; Saris, W H M; Blaak, Ellen E.
In: Nutrients, Vol. 12, No. 2, 339, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - The relationship between circulating acetate and human insulin resistance before and after weight loss in the DiOGenes study
AU - González Hernández, Manuel A
AU - Canfora, Emanuel E
AU - Pasmans, Kenneth
AU - Astrup, Arne
AU - Saris, W H M
AU - Blaak, Ellen E
N1 - CURIS 2020 NEXS 055
PY - 2020
Y1 - 2020
N2 - Microbially-produced acetate has been reported to beneficially affect metabolic health through effects on satiety, energy expenditure, insulin sensitivity, and substrate utilization. Here, we investigate the association between sex-specific concentrations of acetate and insulin sensitivity/resistance indices (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), circulating insulin and Matsuda Index) in the Diet, Obesity and Genes (DiOGenes) Dietary study at baseline and after a low-calorie diet (LCD, 800 kcal/d). In this analysis, 692 subjects (Body Mass Index >27 kg/m2) were included, who underwent an LCD for 8 weeks. Linear mixed models were performed, which were adjusted for mean acetate concentration, center (random factor), age, weight loss, and fat-free mass (FFM). At baseline, no associations between plasma acetate and insulin sensitivity/resistance indices were found. We found a slight positive association between changes in acetate and changes in HOMA-IR (std 0.130, p = 0.033) in women, but not in men (std -0.072, p = 0.310) independently of age, weight loss and FFM. We were not able to confirm previously reported associations between acetate and insulin sensitivity in this large European cohort. The mechanisms behind the sex-specific relationship between LCD-induced changes in acetate and insulin sensitivity require further study.
AB - Microbially-produced acetate has been reported to beneficially affect metabolic health through effects on satiety, energy expenditure, insulin sensitivity, and substrate utilization. Here, we investigate the association between sex-specific concentrations of acetate and insulin sensitivity/resistance indices (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), circulating insulin and Matsuda Index) in the Diet, Obesity and Genes (DiOGenes) Dietary study at baseline and after a low-calorie diet (LCD, 800 kcal/d). In this analysis, 692 subjects (Body Mass Index >27 kg/m2) were included, who underwent an LCD for 8 weeks. Linear mixed models were performed, which were adjusted for mean acetate concentration, center (random factor), age, weight loss, and fat-free mass (FFM). At baseline, no associations between plasma acetate and insulin sensitivity/resistance indices were found. We found a slight positive association between changes in acetate and changes in HOMA-IR (std 0.130, p = 0.033) in women, but not in men (std -0.072, p = 0.310) independently of age, weight loss and FFM. We were not able to confirm previously reported associations between acetate and insulin sensitivity in this large European cohort. The mechanisms behind the sex-specific relationship between LCD-induced changes in acetate and insulin sensitivity require further study.
KW - Faculty of Science
KW - Short chain fatty acids
KW - Obesity
KW - Insulin resistance
KW - Weight loss
U2 - 10.3390/nu12020339
DO - 10.3390/nu12020339
M3 - Journal article
C2 - 32012996
VL - 12
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 339
ER -
ID: 237659729