Whole blood long-chain n-3 fatty acids as a measure of fish oil compliance in children with acute lymphoblastic leukemia: a pilot study
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- Laumann et al_Prostaglandins Leukotrienes and Essential Fatty Acids_2022_Vol 177_e102401
Final published version, 931 KB, PDF document
Long-chain n-3 fatty acids (n-3 LCPUFA) may prevent chemotherapy-induced hyperlipidemia in children with acute lymphoblastic leukemia (ALL). However, compliance could be a problem and intake-biomarker correlations may be affected by bodyweight and blood transfusions. We assessed whole blood n-3 LCPUFA three times during the first 83 days of treatment in six 1-17-year-old children with ALL, who received 2.4-4.9 g/d n-3 LCPUFA depending on bodyweight. Mean compliance was 73%, which resulted in a 2.5-fold increase in blood n-3 LCPUFA irrespective of blood transfusions. The correlation between relative blood content of n-3 LCPUFA and intake in g/d across the study period was strong (r=0.76, p=0.001). When n-3 LCPUFA was expressed in absolute concentrations and intake per kg bodyweight the correlation decreased (r=0.39, p=0.164) and was driven by baseline values. Thus, relative content of n-3 LCPUFA in blood reflects fish oil compliance in children with ALL despite blood transfusions and differences in bodyweight.
Original language | English |
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Article number | 102401 |
Journal | Prostaglandins, Leukotrienes & Essential Fatty Acids |
Volume | 177 |
Number of pages | 5 |
ISSN | 0952-3278 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Copyright © 2022. Published by Elsevier Ltd.
- Faculty of Science - Omega-3 fatty acids, Dose-response-relationship, Dietary biomarkers, Cancer, Acute lymphoblastic leukemia, Children
Research areas
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