1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators
Research output: Contribution to journal › Journal article › Research › peer-review
(S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.
Original language | English |
---|---|
Journal | Journal of Medicinal Chemistry |
Volume | 51 |
Issue number | 20 |
Pages (from-to) | 6614-8 |
ISSN | 0022-2623 |
DOIs | |
Publication status | Published - 2008 |
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 6747715