Analysing the distribution of synaptic vesicles using a spatial point process model
Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: a control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode.
We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.
We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.
Original language | English |
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Title of host publication | Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics |
Number of pages | 6 |
Publisher | Association for Computing Machinery |
Publication date | 2014 |
Pages | 73-78 |
ISBN (Electronic) | 978-1-4503-2894-4 |
DOIs | |
Publication status | Published - 2014 |
Event | 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics - Newport Beach Marriott Hotel & Spa, Newport Beach, United States Duration: 20 Sep 2014 → 23 Sep 2014 Conference number: 5 |
Conference
Conference | 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics |
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Nummer | 5 |
Location | Newport Beach Marriott Hotel & Spa |
Land | United States |
By | Newport Beach |
Periode | 20/09/2014 → 23/09/2014 |
- Faculty of Health and Medical Sciences - Synaptic vesicles distribution, Spatial point process, Serial section transmission electron microscopy images, Stress
Research areas
ID: 159741105