Familial clustering of myocardial infarction in first-degree relatives: a nationwide study
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Familial clustering of myocardial infarction in first-degree relatives : a nationwide study. / Nielsen, Mia; Andersson, Charlotte; Gerds, Thomas A; Andersen, Per Kragh; Jensen, Thomas Bo; Køber, Lars; Gislason, Gunnar; Torp-Pedersen, Christian.
In: European Heart Journal (Online), Vol. 34, No. 16, 2013, p. 1198-1203.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Familial clustering of myocardial infarction in first-degree relatives
T2 - a nationwide study
AU - Nielsen, Mia
AU - Andersson, Charlotte
AU - Gerds, Thomas A
AU - Andersen, Per Kragh
AU - Jensen, Thomas Bo
AU - Køber, Lars
AU - Gislason, Gunnar
AU - Torp-Pedersen, Christian
PY - 2013
Y1 - 2013
N2 - Aims Family history is an established risk factor for myocardial infarction (MI), but it is not clear how this risk changes with number and gender of first-degree relatives with MI. We used the entire Danish population to examine the importance of MI in siblings and parents.Methods and results This study is a retrospective nationwide register-based cohort study including registered relatives to all Danish citizens diagnosed with MI in the period 1978–2010. In the entire Danish population we identified siblings to 7552 patients with a first-time MI. The rate ratios (RR) calculated by Poisson models showed an RR of 4.30 (95% confidence interval 3.53–5.23) for siblings of a patient with MI. Children of parents with MI also showed high risk: for children of a maternal case RR 2.40 (2.20–2.60), and of a paternal case RR 1.98 (1.98–2.09), respectively; P value for gender interaction <0.0001. A paternal case with MI at an age <50 years was associated with an RR of 3.30 (2.92–3.72) while a case >50 years was associated with a risk of 1.83 (1.73–1.93). For maternal cases below and above 50 years of age the risks were 3.23 (2.56–4.10) and 2.31 (2.11–2.52), respectively.Conclusion First-degree relatives of a patient with myocardial infarction themselves have a substantial higher risk of myocardial infarction. The risk is particularly elevated when the MI case is the mother or a sibling, and when the MI case has the infarction before the age of 50 years.
AB - Aims Family history is an established risk factor for myocardial infarction (MI), but it is not clear how this risk changes with number and gender of first-degree relatives with MI. We used the entire Danish population to examine the importance of MI in siblings and parents.Methods and results This study is a retrospective nationwide register-based cohort study including registered relatives to all Danish citizens diagnosed with MI in the period 1978–2010. In the entire Danish population we identified siblings to 7552 patients with a first-time MI. The rate ratios (RR) calculated by Poisson models showed an RR of 4.30 (95% confidence interval 3.53–5.23) for siblings of a patient with MI. Children of parents with MI also showed high risk: for children of a maternal case RR 2.40 (2.20–2.60), and of a paternal case RR 1.98 (1.98–2.09), respectively; P value for gender interaction <0.0001. A paternal case with MI at an age <50 years was associated with an RR of 3.30 (2.92–3.72) while a case >50 years was associated with a risk of 1.83 (1.73–1.93). For maternal cases below and above 50 years of age the risks were 3.23 (2.56–4.10) and 2.31 (2.11–2.52), respectively.Conclusion First-degree relatives of a patient with myocardial infarction themselves have a substantial higher risk of myocardial infarction. The risk is particularly elevated when the MI case is the mother or a sibling, and when the MI case has the infarction before the age of 50 years.
KW - Faculty of Health and Medical Sciences
KW - Familial clustering
KW - Myocardial infarction
KW - First-degree relatives
U2 - 10.1093/eurheartj/ehs475
DO - 10.1093/eurheartj/ehs475
M3 - Journal article
C2 - 23297314
VL - 34
SP - 1198
EP - 1203
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 16
ER -
ID: 117435601