First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization
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The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.
Original language | English |
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Journal | Organic Letters |
Volume | 10 |
Issue number | 23 |
Pages (from-to) | 5353-5356 |
ISSN | 1523-7060 |
DOIs | |
Publication status | Published - 2008 |
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 10162587