Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors
Research output: Contribution to journal › Journal article › Research › peer-review
The synthesis of a series of derivatized flavylium cations was undertaken and the affinity to the benzodiazepine binding site of the GABA-A receptor evaluated. The observed high affinity for some derivatives (sub-muM range) was explained by an in vitro transformation of the flavylium cations into the corresponding trans-retrochalcones, components which are proposed to be the active species in this series.
Original language | English |
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Journal | Bioorganic & Medicinal Chemistry Letters |
Volume | 18 |
Issue number | 17 |
Pages (from-to) | 4864-4867 |
ISSN | 0960-894X |
DOIs | |
Publication status | Published - 2008 |
Bibliographical note
Keywords: Animals; Benzodiazepines; Binding Sites; Brain; Chalcones; Flavonoids; Fluorides; Ligands; Male; Phosphates; Polycyclic Hydrocarbons, Aromatic; Rats; Rats, Wistar; Receptors, GABA-A; Salts
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 10161334