In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration
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In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration. / Pedersen, Brian Thoning; Larsen, Susan Weng; Østergaard, Jesper; Larsen, Claus Selch.
In: Drug Delivery, Vol. 15, No. 1, 2008, p. 23-30.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration
AU - Pedersen, Brian Thoning
AU - Larsen, Susan Weng
AU - Østergaard, Jesper
AU - Larsen, Claus Selch
PY - 2008
Y1 - 2008
N2 - In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspensions have been compared and the sustained release properties from such suspensions formed in situ has been evaluated. The appearance of lidocaine in the acceptor phase after instillation of preformed and in situ formed aqueous and oil suspensions into the small aqueous donor compartment applied to zero-order kinetics as long sufficient amounts of solid lidocaine remained in the donor cell. The obtained data indicate that oil solutions and oil suspensions of lidocaine possess prolonged release properties equal to or better than those of aqueous counterparts. Also the release properties of preformed aqueous and oil suspensions are identical to such suspension types formed in situ. The present in vitro model appears useful in quality control and formulation development in the field of parenteral depots.
AB - In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspensions have been compared and the sustained release properties from such suspensions formed in situ has been evaluated. The appearance of lidocaine in the acceptor phase after instillation of preformed and in situ formed aqueous and oil suspensions into the small aqueous donor compartment applied to zero-order kinetics as long sufficient amounts of solid lidocaine remained in the donor cell. The obtained data indicate that oil solutions and oil suspensions of lidocaine possess prolonged release properties equal to or better than those of aqueous counterparts. Also the release properties of preformed aqueous and oil suspensions are identical to such suspension types formed in situ. The present in vitro model appears useful in quality control and formulation development in the field of parenteral depots.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1080/10717540701828657
DO - 10.1080/10717540701828657
M3 - Journal article
C2 - 18197520
VL - 15
SP - 23
EP - 30
JO - Drug Delivery
JF - Drug Delivery
SN - 1071-7544
IS - 1
ER -
ID: 2998544