A new model for evaluation of thrombosis and ischaemia/reperfusion injury
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: The purpose of the present study was to describe infarct size and platelet accumulation when reperfusion injury was combined with a thrombogenic lesion in the coronary artery. The left anterior descending artery was damaged in 11 pigs and subsequently occluded proximal to the lesion for 50 min, followed by 4 h of reperfusion.
RESULTS: The infarct size/area at risk was 40 (35 63)%. Infarct size correlated with troponin-T-3 h (p=0.85, p<0.002), but not with creatine kinase-3 h. Platelet aggregation decreased by 34% (p<0.01) at 15 min of reperfusion, but returned to baseline. Platelet accumulation in the left ventricle was significantly higher in the area at risk (194 (157-206)%) compared to the right ventricle (137 (120-142)%); p<0.05).
CONCLUSION: A decreased platelet reactivity and increased accumulation of platelets in the area at risk indicates that activated platelets become entrapped in the myocardium. Troponin-T was a better marker of myocardial damage than creatine kinase in this in vivo model with pigs.
Original language | English |
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Journal | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica |
Volume | 108 |
Issue number | 5 |
Pages (from-to) | 373-9 |
Number of pages | 7 |
ISSN | 0903-4641 |
DOIs | |
Publication status | Published - May 2000 |
- Animals, Blood Platelets/physiology, Coronary Thrombosis/diagnosis, Creatine Kinase/biosynthesis, Myocardial Ischemia/diagnosis, Myocardial Reperfusion Injury/diagnosis, Platelet Aggregation, Swine, Troponin T/biosynthesis
Research areas
ID: 243520546