Extensive and interrelated subcortical white and gray matter alterations in preterm-born adults
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Extensive and interrelated subcortical white and gray matter alterations in preterm-born adults. / Meng, C.; Bäuml, J. G.; Daamen, M.; Jaekel, J.; Neitzel, J.; Scheef, L.; Busch, B.; Baumann, N.; Boecker, H.; Zimmer, C.; Bartmann, P.; Wolke, D.; Wohlschläger, A. M.; Sorg, Christian.
In: Brain Structure and Function, Vol. 221, No. 4, 01.05.2016, p. 2109-2121.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Extensive and interrelated subcortical white and gray matter alterations in preterm-born adults
AU - Meng, C.
AU - Bäuml, J. G.
AU - Daamen, M.
AU - Jaekel, J.
AU - Neitzel, J.
AU - Scheef, L.
AU - Busch, B.
AU - Baumann, N.
AU - Boecker, H.
AU - Zimmer, C.
AU - Bartmann, P.
AU - Wolke, D.
AU - Wohlschläger, A. M.
AU - Sorg, Christian
N1 - Publisher Copyright: © 2015, Springer-Verlag Berlin Heidelberg.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Preterm birth is a leading cause for impaired neurocognitive development with an increased risk for persistent cognitive deficits in adulthood. In newborns, preterm birth is associated with interrelated white matter (WM) alterations and deep gray matter (GM) loss; however, little is known about the persistence and relevance of these subcortical brain changes. We tested the hypothesis that the pattern of correspondent subcortical WM and GM changes is present in preterm-born adults and has a brain-injury-like nature, i.e., it predicts lowered general cognitive performance. Eighty-five preterm-born and 69 matched term-born adults were assessed by diffusion- and T1-weighted MRI and cognitive testing. Main outcome measures were fractional anisotropy of water diffusion for WM property, GM volume for GM property, and full-scale IQ for cognitive performance. In preterm-born adults, reduced fractional anisotropy was widely distributed ranging from cerebellum to brainstem to hemispheres. GM volume was reduced in the thalamus, striatum, temporal cortices, and increased in the cingulate cortices. Fractional anisotropy reductions were specifically associated with GM loss in thalamus and striatum, with correlation patterns for both regions extensively overlapping in the WM of brainstem and hemispheres. For overlap regions, fractional anisotropy was positively related with both gestational age and full-scale IQ. Results provide evidence for extensive, interrelated, and adverse WM and GM subcortical changes in preterm-born adults. Data suggest persistent brain-injury-like changes of subcortical–cortical connectivity after preterm delivery.
AB - Preterm birth is a leading cause for impaired neurocognitive development with an increased risk for persistent cognitive deficits in adulthood. In newborns, preterm birth is associated with interrelated white matter (WM) alterations and deep gray matter (GM) loss; however, little is known about the persistence and relevance of these subcortical brain changes. We tested the hypothesis that the pattern of correspondent subcortical WM and GM changes is present in preterm-born adults and has a brain-injury-like nature, i.e., it predicts lowered general cognitive performance. Eighty-five preterm-born and 69 matched term-born adults were assessed by diffusion- and T1-weighted MRI and cognitive testing. Main outcome measures were fractional anisotropy of water diffusion for WM property, GM volume for GM property, and full-scale IQ for cognitive performance. In preterm-born adults, reduced fractional anisotropy was widely distributed ranging from cerebellum to brainstem to hemispheres. GM volume was reduced in the thalamus, striatum, temporal cortices, and increased in the cingulate cortices. Fractional anisotropy reductions were specifically associated with GM loss in thalamus and striatum, with correlation patterns for both regions extensively overlapping in the WM of brainstem and hemispheres. For overlap regions, fractional anisotropy was positively related with both gestational age and full-scale IQ. Results provide evidence for extensive, interrelated, and adverse WM and GM subcortical changes in preterm-born adults. Data suggest persistent brain-injury-like changes of subcortical–cortical connectivity after preterm delivery.
KW - Diffusion MRI
KW - Gray matter
KW - IQ
KW - Preterm-born adults
KW - Voxel-based morphometry
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=84961290034&partnerID=8YFLogxK
U2 - 10.1007/s00429-015-1032-9
DO - 10.1007/s00429-015-1032-9
M3 - Journal article
C2 - 25820473
AN - SCOPUS:84961290034
VL - 221
SP - 2109
EP - 2121
JO - Brain Structure and Function
JF - Brain Structure and Function
SN - 1863-2653
IS - 4
ER -
ID: 393164110