Acute exercise does not induce an acute phase response (APR) in Standardbred trotters
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Acute exercise does not induce an acute phase response (APR) in Standardbred trotters. / Kristensen, Lena; Buhl, Rikke; Nostell, Katarina; Bak, Lars; Petersen, Ellen; Lindholm, Maria; Jacobsen, Stine.
In: Canadian Journal of Veterinary Research, Vol. 78, 2014, p. 97-102.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Acute exercise does not induce an acute phase response (APR) in Standardbred trotters
AU - Kristensen, Lena
AU - Buhl, Rikke
AU - Nostell, Katarina
AU - Bak, Lars
AU - Petersen, Ellen
AU - Lindholm, Maria
AU - Jacobsen, Stine
PY - 2014
Y1 - 2014
N2 - The purpose of the study was to investigate whether acute strenuous exercise (1600- to 2500-m race) would elicit an acute phase response (APR) in Standardbred trotters. Blood levels of several inflammatory markers [serum amyloid A (SAA), haptoglobin, fibrinogen, white blood cell count (WBC), and iron], muscle enzymes [creatinine kinase (CK) and aspartate transaminase (AST)], and hemoglobin were assessed in 58 Standardbred trotters before and after racing. Hemoglobin levels increased and iron levels decreased 12 to 14 h after racing and haptoglobin concentrations, white blood cell counts, and iron levels were decreased 2 and/or 7 d after racing. Concentrations of CK, AST, SAA, and fibrinogen were unaltered in response to racing. Acute strenuous exercise did not elicit an acute phase reaction. The observed acute increase in hemoglobin levels and decreases in haptoglobin and iron levels may have been caused by exercise-induced hemolysis, which indicates that horses might experience a condition similar to athlete’s anemia in humans. The pathogenesis and clinical implications of the hematological and blood-biochemical changes elicited by acute exercise in Standardbred trotters in the present study warrant further investigation
AB - The purpose of the study was to investigate whether acute strenuous exercise (1600- to 2500-m race) would elicit an acute phase response (APR) in Standardbred trotters. Blood levels of several inflammatory markers [serum amyloid A (SAA), haptoglobin, fibrinogen, white blood cell count (WBC), and iron], muscle enzymes [creatinine kinase (CK) and aspartate transaminase (AST)], and hemoglobin were assessed in 58 Standardbred trotters before and after racing. Hemoglobin levels increased and iron levels decreased 12 to 14 h after racing and haptoglobin concentrations, white blood cell counts, and iron levels were decreased 2 and/or 7 d after racing. Concentrations of CK, AST, SAA, and fibrinogen were unaltered in response to racing. Acute strenuous exercise did not elicit an acute phase reaction. The observed acute increase in hemoglobin levels and decreases in haptoglobin and iron levels may have been caused by exercise-induced hemolysis, which indicates that horses might experience a condition similar to athlete’s anemia in humans. The pathogenesis and clinical implications of the hematological and blood-biochemical changes elicited by acute exercise in Standardbred trotters in the present study warrant further investigation
KW - Faculty of Health and Medical Sciences
KW - Horses
KW - equine
KW - Veterinary medicine
KW - Sports Medicine
KW - Inflammation
KW - Acute phase proteins
KW - Serum amyloid A
M3 - Journal article
VL - 78
SP - 97
EP - 102
JO - Canadian Journal of Veterinary Research
JF - Canadian Journal of Veterinary Research
SN - 0830-9000
ER -
ID: 119243119