Effects of organohalogen pollutants on haematological and urine clinical-chemical parameters in Greenland sledge dogs (Canis familiaris)
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Effects of organohalogen pollutants on haematological and urine clinical-chemical parameters in Greenland sledge dogs (Canis familiaris). / Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Letcher, Robert J.; Shahmiri, Soheila; Andersen, Steen; Møller, Per; Olsen, Aage Kristian; Jensen, Asger Lundorff.
In: Ecotoxicology and Environmental Safety, Vol. 69, No. 3, 2008, p. 381-390.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of organohalogen pollutants on haematological and urine clinical-chemical parameters in Greenland sledge dogs (Canis familiaris)
AU - Sonne, Christian
AU - Dietz, Rune
AU - Kirkegaard, Maja
AU - Letcher, Robert J.
AU - Shahmiri, Soheila
AU - Andersen, Steen
AU - Møller, Per
AU - Olsen, Aage Kristian
AU - Jensen, Asger Lundorff
PY - 2008
Y1 - 2008
N2 - Seven West Greenland sledge dog bitches (Canis familiaris) and their three pups were fed 50-200 g of contaminated West Greenland minke whale (Balaenoptera acutorostrata) blubber, and in a control cohort eight sister bitches and their .ve pups were fed a similar amount pork fat. Blood plasma and urine clinical-chemical parameters were measured and compared between the bitches and pups form the control and exposed cohorts. Based on existing reference intervals, Arctic mammals may have blood clinical-chemical endpoint levels that differ from comparable species at lower latitudes. The cortisol:creatinine ratio, protein:creatinine ratio, alkaline phosphatase, cholesterol and inorganic phosphate were signi.cantly highest (ANCOVA: all po0:05) in the pup generation. The cortisol:creatinine ratio, cholesterol, lactate dehydrogenase and creatinine kinase were signi.cantly higher (ANCOVA: all po0:05) in the control group, while glucose was signi.cantly highest (ANCOVA: po0:05) in the exposed group. Furthermore, the blood cholesterol levels indicate that exposure via the diet to marine mammal blubber has a preventive effect on the development of cardiovascular diseases. We therefore suggest that the consumption of contaminated Arctic marine blubber impacted liver and kidney function in adult and pup sledge dogs.
AB - Seven West Greenland sledge dog bitches (Canis familiaris) and their three pups were fed 50-200 g of contaminated West Greenland minke whale (Balaenoptera acutorostrata) blubber, and in a control cohort eight sister bitches and their .ve pups were fed a similar amount pork fat. Blood plasma and urine clinical-chemical parameters were measured and compared between the bitches and pups form the control and exposed cohorts. Based on existing reference intervals, Arctic mammals may have blood clinical-chemical endpoint levels that differ from comparable species at lower latitudes. The cortisol:creatinine ratio, protein:creatinine ratio, alkaline phosphatase, cholesterol and inorganic phosphate were signi.cantly highest (ANCOVA: all po0:05) in the pup generation. The cortisol:creatinine ratio, cholesterol, lactate dehydrogenase and creatinine kinase were signi.cantly higher (ANCOVA: all po0:05) in the control group, while glucose was signi.cantly highest (ANCOVA: po0:05) in the exposed group. Furthermore, the blood cholesterol levels indicate that exposure via the diet to marine mammal blubber has a preventive effect on the development of cardiovascular diseases. We therefore suggest that the consumption of contaminated Arctic marine blubber impacted liver and kidney function in adult and pup sledge dogs.
KW - Former LIFE faculty
KW - Blood
KW - Cholesterol
KW - Cortisol:creatinine ratio
KW - Glucose
KW - Kidney
KW - Lactate dehydrogenase (LDH)
KW - Liver
KW - Polychlorinated biphenyls (PCBs)
KW - Sledge dogs
KW - Urine
U2 - 10.1016/j.ecoenv.2007.03.002
DO - 10.1016/j.ecoenv.2007.03.002
M3 - Journal article
C2 - 17434585
VL - 69
SP - 381
EP - 390
JO - Ecotoxicology and Environmental Safety
JF - Ecotoxicology and Environmental Safety
SN - 0147-6513
IS - 3
ER -
ID: 8096516