The minor collagens in articular cartilage
Research output: Contribution to journal › Review › Research › peer-review
Standard
The minor collagens in articular cartilage. / Luo, Yunyun; Sinkeviciute, Dovile; He, Yi; Karsdal, Morten; Henrotin, Yves; Mobasheri, Ali ; Onnerfjord, Patrik; Bay-Jensen, Anne-Christine.
In: Protein & Cell (Online), Vol. 8, No. 8, 2017, p. 560-572.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The minor collagens in articular cartilage
AU - Luo, Yunyun
AU - Sinkeviciute, Dovile
AU - He, Yi
AU - Karsdal, Morten
AU - Henrotin, Yves
AU - Mobasheri, Ali
AU - Onnerfjord, Patrik
AU - Bay-Jensen, Anne-Christine
PY - 2017
Y1 - 2017
N2 - Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.
AB - Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.
KW - Faculty of Health and Medical Sciences
U2 - 10.1007/s13238-017-0377-7
DO - 10.1007/s13238-017-0377-7
M3 - Review
C2 - 28213717
VL - 8
SP - 560
EP - 572
JO - Protein & Cell (Online)
JF - Protein & Cell (Online)
SN - 1674-8018
IS - 8
ER -
ID: 173503299