1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection
Research output: Contribution to conference › Poster › Research
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1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection. / Bragstad, Karoline; Martel, Cyril Jean-Marie; Aasted, Bent; Nielsen, Lars Peter; Fomsgaard, Anders.
2008. Poster session presented at European Influenza Conference, Vilamoura, Portugal.Research output: Contribution to conference › Poster › Research
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TY - CONF
T1 - 1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection
AU - Bragstad, Karoline
AU - Martel, Cyril Jean-Marie
AU - Aasted, Bent
AU - Nielsen, Lars Peter
AU - Fomsgaard, Anders
N1 - Conference code: 3
PY - 2008
Y1 - 2008
N2 - Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein. These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants.
AB - Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein. These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants.
KW - Former LIFE faculty
KW - DNA vaccine
KW - Ferret
KW - 1918
M3 - Poster
Y2 - 14 September 2008 through 17 September 2008
ER -
ID: 8114293