Haematological and biochemical changes in dogs naturally infected with Angiostrongylus vasorum before and after treatment
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Haematological and biochemical changes in dogs naturally infected with Angiostrongylus vasorum before and after treatment. / Willesen, Jakob; Jensen, Asger Lundorff; Kristensen, Annemarie Thuri; Koch, Jørgen.
In: Veterinary Journal, Vol. 180, No. 1, 2009, p. 106-111.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Haematological and biochemical changes in dogs naturally infected with Angiostrongylus vasorum before and after treatment
AU - Willesen, Jakob
AU - Jensen, Asger Lundorff
AU - Kristensen, Annemarie Thuri
AU - Koch, Jørgen
PY - 2009
Y1 - 2009
N2 - Haematological and biochemical parameters were studied prospectively in 48 dogs naturally infected with Angiostrongylus vasorum in a primary care setting. Samples for analysis were obtained when treatment was started and 42 days afterwards. Prior to treatment, 21% of affected dogs exhibited eosinophilia, whereas increased total white blood cell (WBC) counts and neutrophilia were observed in only 4.2%. WBC counts and concentrations of neutrophils, eosinophils and monocytes decreased significantly from days 0 to 42, indicating that, even in dogs without elevated absolute blood values, a low grade inflammatory response may be present in dogs with A. vasorum infection. Biochemical changes (especially an increase in serum globulins and a decrease in serum fructosamine) were in agreement with the findings of other studies. The results show that the diagnosis of canine angiostrongylosis should not be excluded based on unremarkable haematological and blood biochemical parameters. They also support our recent finding that a low serum fructosamine concentration may be associated with infection with A. vasorum.
AB - Haematological and biochemical parameters were studied prospectively in 48 dogs naturally infected with Angiostrongylus vasorum in a primary care setting. Samples for analysis were obtained when treatment was started and 42 days afterwards. Prior to treatment, 21% of affected dogs exhibited eosinophilia, whereas increased total white blood cell (WBC) counts and neutrophilia were observed in only 4.2%. WBC counts and concentrations of neutrophils, eosinophils and monocytes decreased significantly from days 0 to 42, indicating that, even in dogs without elevated absolute blood values, a low grade inflammatory response may be present in dogs with A. vasorum infection. Biochemical changes (especially an increase in serum globulins and a decrease in serum fructosamine) were in agreement with the findings of other studies. The results show that the diagnosis of canine angiostrongylosis should not be excluded based on unremarkable haematological and blood biochemical parameters. They also support our recent finding that a low serum fructosamine concentration may be associated with infection with A. vasorum.
KW - Former LIFE faculty
KW - Angiostrongylus vasorum
KW - Haematology
KW - Biochemistry
KW - Inflammation
U2 - 10.1016/j.tvjl.2007.10.018
DO - 10.1016/j.tvjl.2007.10.018
M3 - Journal article
C2 - 18083051
VL - 180
SP - 106
EP - 111
JO - The Veterinary Journal
JF - The Veterinary Journal
SN - 1090-0233
IS - 1
ER -
ID: 8098128