Serum C-reactive protein concentration as an indicator of remission status in dogs with multicentric lymphoma
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Serum C-reactive protein concentration as an indicator of remission status in dogs with multicentric lymphoma. / Nielsen, Lise; Toft, Nils; Eckersall, David; Mellor, Dominic J.; Morris, Joanna S.
In: Journal of Veterinary Internal Medicine, Vol. 21, No. 6, 2007, p. 1231-1236.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Serum C-reactive protein concentration as an indicator of remission status in dogs with multicentric lymphoma
AU - Nielsen, Lise
AU - Toft, Nils
AU - Eckersall, David
AU - Mellor, Dominic J.
AU - Morris, Joanna S.
PY - 2007
Y1 - 2007
N2 - Background: The acute-phase protein C-reactive protein (CRP) is used as a diagnostic and prognostic marker in humans with various neoplasias, including non-Hodgkin's lymphoma.Objective: To evaluate if CRP could be used to detect different remission states in dogs with lymphoma.Animals: Twenty-two dogs with untreated multicentric lymphoma.Methods: Prospective observational study. Blood samples were collected at the time of diagnosis, before each chemotherapy session, and at follow-up visits, resulting in 287 serum samples.Results: Before therapy, a statistically significant majority of the dogs (P = .0019) had CRP concentrations above the reference range (68%, 15/22). After achieving complete remission 90% (18/20) of the dogs had CRP concentrations within the reference range, and the difference in values before and after treatment was statistically significant (P < .001). CRP concentrations of dogs in complete remission (median, 1.91; range, 0.2-103) were significantly different (P = .031) from those of dogs with partial remission (median, 2.48; range, 0-89), stable disease (median, 1.77; range, 1.03-42.65), or progressive disease (median, 8.7; range, 0-82.5). There was profound variation of CRP measurements within each dog.Conclusions: CRP is useful in determining complete remission status after treatment with cytotoxic drugs. However, the individual variation between dogs means CRP concentration is not sufficiently different in other remission states to permit its use in monitoring progression of the disease. Greater reliability in determining remission status might be achieved by combining CRP concentration with other serum markers.
AB - Background: The acute-phase protein C-reactive protein (CRP) is used as a diagnostic and prognostic marker in humans with various neoplasias, including non-Hodgkin's lymphoma.Objective: To evaluate if CRP could be used to detect different remission states in dogs with lymphoma.Animals: Twenty-two dogs with untreated multicentric lymphoma.Methods: Prospective observational study. Blood samples were collected at the time of diagnosis, before each chemotherapy session, and at follow-up visits, resulting in 287 serum samples.Results: Before therapy, a statistically significant majority of the dogs (P = .0019) had CRP concentrations above the reference range (68%, 15/22). After achieving complete remission 90% (18/20) of the dogs had CRP concentrations within the reference range, and the difference in values before and after treatment was statistically significant (P < .001). CRP concentrations of dogs in complete remission (median, 1.91; range, 0.2-103) were significantly different (P = .031) from those of dogs with partial remission (median, 2.48; range, 0-89), stable disease (median, 1.77; range, 1.03-42.65), or progressive disease (median, 8.7; range, 0-82.5). There was profound variation of CRP measurements within each dog.Conclusions: CRP is useful in determining complete remission status after treatment with cytotoxic drugs. However, the individual variation between dogs means CRP concentration is not sufficiently different in other remission states to permit its use in monitoring progression of the disease. Greater reliability in determining remission status might be achieved by combining CRP concentration with other serum markers.
KW - Former LIFE faculty
KW - Acute phase protein
KW - Complete remission
KW - C-reactive protein
KW - Serum markers
U2 - 10.1111/j.1939-1676.2007.tb01943.x
DO - 10.1111/j.1939-1676.2007.tb01943.x
M3 - Journal article
VL - 21
SP - 1231
EP - 1236
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 6
ER -
ID: 8097746