Stem cell therapy for joint problems using the horse as a clinically relevant animal model
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Stem cell therapy for joint problems using the horse as a clinically relevant animal model. / Koch, Thomas Gadegaard; Betts, Dean H.
In: Expert Opinion on Biological Therapy, Vol. 7, No. 11, 2007, p. 1621-1626.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Stem cell therapy for joint problems using the horse as a clinically relevant animal model
AU - Koch, Thomas Gadegaard
AU - Betts, Dean H.
PY - 2007
Y1 - 2007
N2 - Research into articular cartilage is a surprisingly recent endeavour and much remains to be learned about the normal development of the synovial joint and its components that interplay in osteoarthritis and focal cartilage defects. Stem cell research is likely to contribute to the understanding of the developmental biology of synovial joints and their pathologies. Before human clinical trials are undertaken, stem cell-based therapies for non-life-threatening disorders should be evaluated for their safety and efficacy using animal models of spontaneous disease and not solely by the existing laboratory models of experimentally induced lesions. The horse lends itself as a good animal model of spontaneous joint disorders that are clinically relevant to similar human disorders. Equine stem cell and tissue engineering studies may be financially feasible to principal investigators and small biotechnology companies if the equine industry is successfully engaged in the research process.
AB - Research into articular cartilage is a surprisingly recent endeavour and much remains to be learned about the normal development of the synovial joint and its components that interplay in osteoarthritis and focal cartilage defects. Stem cell research is likely to contribute to the understanding of the developmental biology of synovial joints and their pathologies. Before human clinical trials are undertaken, stem cell-based therapies for non-life-threatening disorders should be evaluated for their safety and efficacy using animal models of spontaneous disease and not solely by the existing laboratory models of experimentally induced lesions. The horse lends itself as a good animal model of spontaneous joint disorders that are clinically relevant to similar human disorders. Equine stem cell and tissue engineering studies may be financially feasible to principal investigators and small biotechnology companies if the equine industry is successfully engaged in the research process.
KW - Former LIFE faculty
KW - animal models
KW - cartilage
KW - domestic animals
KW - equine
KW - osteoarthritis
KW - stem cells
KW - tissue engineering
U2 - 10.1517/14712598.7.11.1621
DO - 10.1517/14712598.7.11.1621
M3 - Journal article
C2 - 17961087
VL - 7
SP - 1621
EP - 1626
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
SN - 1471-2598
IS - 11
ER -
ID: 8101880