Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies
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Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies. / Jensen, Trine Hammer; Nielsen, Line; Aasted, Bent; Pertoldi, Cino; Blixenkrone-Møller, Merete.
In: Vaccine, Vol. 33, No. 11, 2015, p. 1375-1381.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies
AU - Jensen, Trine Hammer
AU - Nielsen, Line
AU - Aasted, Bent
AU - Pertoldi, Cino
AU - Blixenkrone-Møller, Merete
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Canine distemper virus (CDV) is highly contagious and can cause severe disease against which conventional live vaccines are ineffective in the presence of maternal antibodies. Vaccination in the presences of maternal antibodies was challenged by vaccination of 5 days old and 3 weeks old mink kits with CDV DNA vaccines. Virus neutralising (VN) antibody responses were induced in mink kits vaccinated with a plasmid encoding the haemaglutinin protein (H) of CDV (n=5, pCDV-H) or a combination of the H, fusion (F) and nucleoprotein (N) of CDV (n=5, pCDV-HFN). These DNA vaccinated kits were protected against virulent experimental infection with field strains of CDV. The pCDV-H was more efficient in inducing protective immunity in the presence of maternal antibodies compared to the pCDV-HFN. The results show that DNA vaccination with the pCDV-H or pCDV-HFN (n=4) only given once at 5 days of age induces virus specific immune response in neonatal mink and protection against virulent CDV exposure later in life.
AB - Canine distemper virus (CDV) is highly contagious and can cause severe disease against which conventional live vaccines are ineffective in the presence of maternal antibodies. Vaccination in the presences of maternal antibodies was challenged by vaccination of 5 days old and 3 weeks old mink kits with CDV DNA vaccines. Virus neutralising (VN) antibody responses were induced in mink kits vaccinated with a plasmid encoding the haemaglutinin protein (H) of CDV (n=5, pCDV-H) or a combination of the H, fusion (F) and nucleoprotein (N) of CDV (n=5, pCDV-HFN). These DNA vaccinated kits were protected against virulent experimental infection with field strains of CDV. The pCDV-H was more efficient in inducing protective immunity in the presence of maternal antibodies compared to the pCDV-HFN. The results show that DNA vaccination with the pCDV-H or pCDV-HFN (n=4) only given once at 5 days of age induces virus specific immune response in neonatal mink and protection against virulent CDV exposure later in life.
KW - Faculty of Health and Medical Sciences
KW - Canine distemper virus
KW - Morbillivirus
KW - Neonatal
KW - Mink
KW - Maternal antibodies
KW - DNA vaccination
U2 - 10.1016/j.vaccine.2015.01.029
DO - 10.1016/j.vaccine.2015.01.029
M3 - Journal article
C2 - 25637861
VL - 33
SP - 1375
EP - 1381
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 11
ER -
ID: 132682872