Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice
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Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice. / Jørgensen, Bettina Merete Pyndt; Winther, Gudrun; Kihl, Pernille; Nielsen, Dennis Sandris; Wegener, Gregers; Hansen, Axel Kornerup; Sørensen, Dorte Bratbo.
In: Acta Neuropsychiatrica (Print), Vol. 27, No. 5, 2015, p. 307-311.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice
AU - Jørgensen, Bettina Merete Pyndt
AU - Winther, Gudrun
AU - Kihl, Pernille
AU - Nielsen, Dennis Sandris
AU - Wegener, Gregers
AU - Hansen, Axel Kornerup
AU - Sørensen, Dorte Bratbo
PY - 2015
Y1 - 2015
N2 - OBJECTIVE: Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.METHODS: We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.RESULTS: We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.CONCLUSION: Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.
AB - OBJECTIVE: Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.METHODS: We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.RESULTS: We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.CONCLUSION: Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.
KW - Faculty of Health and Medical Sciences
KW - animal models
KW - anxiety
KW - gut microbiota
KW - magnesium
U2 - 10.1017/neu.2015.10
DO - 10.1017/neu.2015.10
M3 - Journal article
C2 - 25773775
VL - 27
SP - 307
EP - 311
JO - Acta Neuropsychiatrica
JF - Acta Neuropsychiatrica
SN - 0924-2708
IS - 5
ER -
ID: 144794944