Neuroticism in remitted major depression: Elevated with early onset but not late onset of depression
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Neuroticism in remitted major depression : Elevated with early onset but not late onset of depression. / Gade, Anders; Kristoffersen, Marius; Kessing, Lars Vedel.
In: Psychopathology, Vol. 48, No. 6, 2015, p. 400-407.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neuroticism in remitted major depression
T2 - Elevated with early onset but not late onset of depression
AU - Gade, Anders
AU - Kristoffersen, Marius
AU - Kessing, Lars Vedel
PY - 2015
Y1 - 2015
N2 - BACKGROUND: The personality trait of neuroticism is strongly related to depression, but depression is etiologically heterogeneous. Late-onset depression (LOD) may be more closely related to vascular factors, and previous studies of neuroticism in LOD versus early-onset depression (EOD) have not been consistent. METHOD: We examined neuroticism, extraversion and perceived stress in 88 fully remitted depressed patients with a mean age of 60 years and with a history of hospitalization for major depressive disorder. Patients were divided into those with onset after and those with onset before 50 years of age (LOD and EOD, respectively), and the two groups were compared both with each other and with matched control groups of healthy subjects. RESULTS: EOD patients showed increased levels of neuroticism in comparison with both LOD and matched controls, who did not differ. The association between age of onset and neuroticism was confirmed in analyses based on age of depression onset as a continuous variable. CONCLUSION: Neuroticism may be an etiological factor in EOD but not or less so in LOD. This finding contributes to the growing evidence for etiological differences between early- and late-onset late-life depression
AB - BACKGROUND: The personality trait of neuroticism is strongly related to depression, but depression is etiologically heterogeneous. Late-onset depression (LOD) may be more closely related to vascular factors, and previous studies of neuroticism in LOD versus early-onset depression (EOD) have not been consistent. METHOD: We examined neuroticism, extraversion and perceived stress in 88 fully remitted depressed patients with a mean age of 60 years and with a history of hospitalization for major depressive disorder. Patients were divided into those with onset after and those with onset before 50 years of age (LOD and EOD, respectively), and the two groups were compared both with each other and with matched control groups of healthy subjects. RESULTS: EOD patients showed increased levels of neuroticism in comparison with both LOD and matched controls, who did not differ. The association between age of onset and neuroticism was confirmed in analyses based on age of depression onset as a continuous variable. CONCLUSION: Neuroticism may be an etiological factor in EOD but not or less so in LOD. This finding contributes to the growing evidence for etiological differences between early- and late-onset late-life depression
KW - Faculty of Health and Medical Sciences
KW - Depression
KW - age of onset
KW - neuroticism
U2 - 10.1159/000440813
DO - 10.1159/000440813
M3 - Journal article
VL - 48
SP - 400
EP - 407
JO - Psychopathology
JF - Psychopathology
SN - 0254-4962
IS - 6
ER -
ID: 153318441