Physical activity and fat-free mass during growth and in later life
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Physical activity and fat-free mass during growth and in later life. / Westerterp, Klaas R; Yamada, Yosuke; Sagayama, Hiroyuki; Ainslie, Philip N; Andersen, Lene F; Anderson, Liam J; Arab, Lenore; Sjödin, Anders Mikael; Wood, Brian M; Wong, William W; Speakman, John R; International Atomic Energy Agency Doubly Labeled Water database group.
In: American Journal of Clinical Nutrition, Vol. 114, No. 5, 2021, p. 1583-1589.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Physical activity and fat-free mass during growth and in later life
AU - Westerterp, Klaas R
AU - Yamada, Yosuke
AU - Sagayama, Hiroyuki
AU - Ainslie, Philip N
AU - Andersen, Lene F
AU - Anderson, Liam J
AU - Arab, Lenore
AU - Baddou, Issaad
AU - Bedu-Addo, Kweku
AU - Blaak, Ellen E
AU - Blanc, Stephane
AU - Bonomi, Alberto G
AU - Bouten, Carlijn V C
AU - Bovet, Pascal
AU - Buchowski, Maciej S
AU - Butte, Nancy F
AU - Camps, Stefan G J A
AU - Close, Graeme L
AU - Cooper, Jamie A
AU - Das, Sai K
AU - Cooper, Richard
AU - Dugas, Lara R
AU - Ekelund, Ulf
AU - Entringer, Sonja
AU - Forrester, Terrence
AU - Fudge, Barry W
AU - Goris, Annelies H
AU - Gurven, Michael
AU - Hambly, Catherine
AU - El Hamdouchi, Asmaa
AU - Hoos, Marije B
AU - Hu, Sumei
AU - Joonas, Noorjehan
AU - Joosen, Annemiek M
AU - Katzmarzyk, Peter
AU - Kempen, Kitty P
AU - Kimura, Misaka
AU - Kraus, William E
AU - Kushner, Robert F
AU - Lambert, Estelle V
AU - Leonard, William R
AU - Lessan, Nader
AU - Martin, Corby K
AU - Medin, Anine C
AU - Meijer, Erwin P
AU - Morehen, James C
AU - Morton, James P
AU - Neuhouser, Marian L
AU - Sjödin, Anders Mikael
AU - Wood, Brian M
AU - Wong, William W
AU - Speakman, John R
AU - International Atomic Energy Agency Doubly Labeled Water database group
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
PY - 2021
Y1 - 2021
N2 - Background: Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass.Objectives: A study is presented of the association between FFM and physical activity in relation to age.Methods: In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution.Results: PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males < 18 y old, and 32% and 47% of the variation in FFM in females and males ≥ 18 y old, respectively. In participants < 18 y old, mean FM-adjusted FFM was 1.7 kg (95% CI: 0.1, 3.2 kg) and 3.4 kg (95% CI: 1.0, 5.6 kg) higher in a very active participant with PAL = 2.0 than in a sedentary participant with PAL = 1.5, for females and males, respectively. At age 18 y, height and FM-adjusted FFM was 3.6 kg (95% CI: 2.8, 4.4 kg) and 4.4 kg (95% CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95% CI: -0.2, 1.7 kg) and 1.0 kg (95% CI: -0.1, 2.1 kg) higher, in a participant with PAL = 2.0 than in a participant with PAL = 1.5, for females and males, respectively.Conclusions: If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults.
AB - Background: Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass.Objectives: A study is presented of the association between FFM and physical activity in relation to age.Methods: In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution.Results: PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males < 18 y old, and 32% and 47% of the variation in FFM in females and males ≥ 18 y old, respectively. In participants < 18 y old, mean FM-adjusted FFM was 1.7 kg (95% CI: 0.1, 3.2 kg) and 3.4 kg (95% CI: 1.0, 5.6 kg) higher in a very active participant with PAL = 2.0 than in a sedentary participant with PAL = 1.5, for females and males, respectively. At age 18 y, height and FM-adjusted FFM was 3.6 kg (95% CI: 2.8, 4.4 kg) and 4.4 kg (95% CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95% CI: -0.2, 1.7 kg) and 1.0 kg (95% CI: -0.1, 2.1 kg) higher, in a participant with PAL = 2.0 than in a participant with PAL = 1.5, for females and males, respectively.Conclusions: If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults.
KW - Adipose Tissue/metabolism
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Body Composition
KW - Child
KW - Child, Preschool
KW - Cross-Sectional Studies
KW - Energy Metabolism
KW - Exercise
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Young Adult
KW - Faculty of Science
KW - Physical activity level
KW - Age
KW - Energy expenditure
KW - Body composition
KW - Doubly labeled water
U2 - 10.1093/ajcn/nqab260
DO - 10.1093/ajcn/nqab260
M3 - Journal article
C2 - 34477824
VL - 114
SP - 1583
EP - 1589
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 5
ER -
ID: 290726558