Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands
Research output: Contribution to journal › Journal article › Research › peer-review
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.
Original language | English |
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Journal | Bioorganic & Medicinal Chemistry Letters |
Volume | 20 |
Issue number | 18 |
Pages (from-to) | 5431-5433 |
ISSN | 0960-894X |
DOIs | |
Publication status | Published - 15 Sep 2010 |
- Cell Line, Hela Cells, Humans, Indoles, Ligands, Protein Binding, Pyrazines, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, Structure-Activity Relationship
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 34207860