Prognostic role of syncytin expression in breast cancer
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Prognostic role of syncytin expression in breast cancer. / Larsson, Lars-Inge; Holck, Susanne; Christensen, Ib Jarle.
In: Human Pathology, Vol. 38, No. 5, 2007, p. 726-731.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic role of syncytin expression in breast cancer
AU - Larsson, Lars-Inge
AU - Holck, Susanne
AU - Christensen, Ib Jarle
PY - 2007
Y1 - 2007
N2 - Breast cancer cells were recently found to produce syncytin, an endogenous retroviral protein implicated in cell fusion, immune regulation, and nitric oxide synthase expression. To determine whether syncytin has a prognostic role in breast cancer, we investigated a series of 165 premenopausal lymph node-negative women for syncytin expression using an immunocytochemical scoring system. Results were analyzed with the Kaplan-Meier method and with the Cox proportional hazard model. Syncytin expression was observed in 38% of the patients, and the degree of syncytin expression constituted a positive prognostic indicator for recurrence-free survival. In addition, we examined a second series of 54 consecutively operated breast cancer patients of all categories and the results supported the conclusions made from the first study. Thus, syncytin expression constitutes a positive prognostic factor in breast cancer - a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and entodhelial cells.
AB - Breast cancer cells were recently found to produce syncytin, an endogenous retroviral protein implicated in cell fusion, immune regulation, and nitric oxide synthase expression. To determine whether syncytin has a prognostic role in breast cancer, we investigated a series of 165 premenopausal lymph node-negative women for syncytin expression using an immunocytochemical scoring system. Results were analyzed with the Kaplan-Meier method and with the Cox proportional hazard model. Syncytin expression was observed in 38% of the patients, and the degree of syncytin expression constituted a positive prognostic indicator for recurrence-free survival. In addition, we examined a second series of 54 consecutively operated breast cancer patients of all categories and the results supported the conclusions made from the first study. Thus, syncytin expression constitutes a positive prognostic factor in breast cancer - a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and entodhelial cells.
KW - Former LIFE faculty
KW - Syncytin
KW - Retroviral envelope protein
KW - Breast cancer
KW - Immunocytochemistry
KW - Prognosis
U2 - 10.1016/j.humpath.2006.10.018
DO - 10.1016/j.humpath.2006.10.018
M3 - Journal article
C2 - 17306327
VL - 38
SP - 726
EP - 731
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 5
ER -
ID: 8069272