The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies
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- The_relationship_between_genetic_2017_accepted
Accepted author manuscript, 910 KB, PDF document
Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.
Original language | English |
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Journal | Neuroscience & Biobehavioral Reviews |
Volume | 79 |
Pages (from-to) | 87-109 |
ISSN | 0149-7634 |
DOIs | |
Publication status | Published - Aug 2017 |
- Faculty of Social Sciences - Bipolar disorder, Genetic polymorphisms, Neuroimaging, Magnetic resonance imaging, Functional MRI, Diffusion tensor imagingvoxel based morphometry
Research areas
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