4.5S RNA: does form predict function?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

4.5S RNA: does form predict function? / Brown, S.

In: The New Biologist, Vol. 3, No. 5, 1991, p. 430-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brown, S 1991, '4.5S RNA: does form predict function?', The New Biologist, vol. 3, no. 5, pp. 430-8. <http://www.ncbi.nlm.nih.gov/pubmed/1715753>

APA

Brown, S. (1991). 4.5S RNA: does form predict function? The New Biologist, 3(5), 430-8. http://www.ncbi.nlm.nih.gov/pubmed/1715753

Vancouver

Brown S. 4.5S RNA: does form predict function? The New Biologist. 1991;3(5):430-8.

Author

Brown, S. / 4.5S RNA: does form predict function?. In: The New Biologist. 1991 ; Vol. 3, No. 5. pp. 430-8.

Bibtex

@article{c8f07bb0d29011dd9473000ea68e967b,
title = "4.5S RNA: does form predict function?",
abstract = "4.5S RNA is a stable RNA of Escherichia coli, and functional homologs of the molecule apparently exist in all prokaryotes: eubacteria, archebacteria, and mycoplasma. Genetic and physiological measurements of the function of 4.5S RNA in E. coli indicate a role for this RNA in protein synthesis. A conserved domain of 4.5S RNA displays structural similarity with the eukaryotic 7S RNA that functions in protein secretion. Although complementation by eukaryotic 7S RNAs remains to be demonstrated, a number of archaebacterial 7S RNAs are able to replace 4.5S RNA for growth of E. coli, and 4.5S RNA is able to mediate a number of 7S RNA functions in vitro. Surprisingly, no effects on protein secretion in E. coli have been directly attributed to 4.5S RNA. These observations raise the question of whether molecules of similar structure necessarily perform the same function.",
author = "S Brown",
note = "Keywords: Base Sequence; Escherichia coli; Humans; Molecular Sequence Data; Protein Biosynthesis; RNA; RNA, Bacterial; RNA, Small Nuclear; Ribosomes; Sequence Homology, Nucleic Acid; Structure-Activity Relationship",
year = "1991",
language = "English",
volume = "3",
pages = "430--8",
journal = "The New Biologist",
issn = "1043-4674",
publisher = "W.B.Saunders Co.",
number = "5",

}

RIS

TY - JOUR

T1 - 4.5S RNA: does form predict function?

AU - Brown, S

N1 - Keywords: Base Sequence; Escherichia coli; Humans; Molecular Sequence Data; Protein Biosynthesis; RNA; RNA, Bacterial; RNA, Small Nuclear; Ribosomes; Sequence Homology, Nucleic Acid; Structure-Activity Relationship

PY - 1991

Y1 - 1991

N2 - 4.5S RNA is a stable RNA of Escherichia coli, and functional homologs of the molecule apparently exist in all prokaryotes: eubacteria, archebacteria, and mycoplasma. Genetic and physiological measurements of the function of 4.5S RNA in E. coli indicate a role for this RNA in protein synthesis. A conserved domain of 4.5S RNA displays structural similarity with the eukaryotic 7S RNA that functions in protein secretion. Although complementation by eukaryotic 7S RNAs remains to be demonstrated, a number of archaebacterial 7S RNAs are able to replace 4.5S RNA for growth of E. coli, and 4.5S RNA is able to mediate a number of 7S RNA functions in vitro. Surprisingly, no effects on protein secretion in E. coli have been directly attributed to 4.5S RNA. These observations raise the question of whether molecules of similar structure necessarily perform the same function.

AB - 4.5S RNA is a stable RNA of Escherichia coli, and functional homologs of the molecule apparently exist in all prokaryotes: eubacteria, archebacteria, and mycoplasma. Genetic and physiological measurements of the function of 4.5S RNA in E. coli indicate a role for this RNA in protein synthesis. A conserved domain of 4.5S RNA displays structural similarity with the eukaryotic 7S RNA that functions in protein secretion. Although complementation by eukaryotic 7S RNAs remains to be demonstrated, a number of archaebacterial 7S RNAs are able to replace 4.5S RNA for growth of E. coli, and 4.5S RNA is able to mediate a number of 7S RNA functions in vitro. Surprisingly, no effects on protein secretion in E. coli have been directly attributed to 4.5S RNA. These observations raise the question of whether molecules of similar structure necessarily perform the same function.

M3 - Journal article

C2 - 1715753

VL - 3

SP - 430

EP - 438

JO - The New Biologist

JF - The New Biologist

SN - 1043-4674

IS - 5

ER -

ID: 9298303