A tale of two rhythms: Locked clocks and chaos in biology
Research output: Contribution to journal › Review › Research › peer-review
Standard
A tale of two rhythms : Locked clocks and chaos in biology. / Heltberg, Mathias L.; Krishna, Sandeep; Kadanoff, Leo P.; Jensen, Mogens H.
In: Cell Systems, Vol. 12, No. 4, 21.04.2021, p. 291-303.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A tale of two rhythms
T2 - Locked clocks and chaos in biology
AU - Heltberg, Mathias L.
AU - Krishna, Sandeep
AU - Kadanoff, Leo P.
AU - Jensen, Mogens H.
PY - 2021/4/21
Y1 - 2021/4/21
N2 - The fundamental mechanisms that control and regulate biological organisms exhibit a surprising level of complexity. Oscillators are perhaps the simplest motifs that produce time-varying dynamics and are ubiquitous in biological systems. It is also known that such biological oscillators interact with each other-for instance, circadian oscillators affect the cell cycle, and somitogenesis clock proteins in adjacent cells affect each other in developing embryos. Therefore, it is vital to understand the effects that can emerge from non-linear interaction between oscillations. Here, we show how oscillations typically arise in biology and take the reader on a tour through the great variety in dynamics that can emerge even from a single pair of coupled oscillators. We explain how chaotic dynamics can emerge and outline the methods of detecting this in experimental time traces. Finally, we discuss the potential role of such complex dynamical features in biological systems.
AB - The fundamental mechanisms that control and regulate biological organisms exhibit a surprising level of complexity. Oscillators are perhaps the simplest motifs that produce time-varying dynamics and are ubiquitous in biological systems. It is also known that such biological oscillators interact with each other-for instance, circadian oscillators affect the cell cycle, and somitogenesis clock proteins in adjacent cells affect each other in developing embryos. Therefore, it is vital to understand the effects that can emerge from non-linear interaction between oscillations. Here, we show how oscillations typically arise in biology and take the reader on a tour through the great variety in dynamics that can emerge even from a single pair of coupled oscillators. We explain how chaotic dynamics can emerge and outline the methods of detecting this in experimental time traces. Finally, we discuss the potential role of such complex dynamical features in biological systems.
KW - NF-KAPPA-B
KW - DISSIPATIVE SYSTEMS
KW - JOSEPHSON-JUNCTION
KW - QUASI-PERIODICITY
KW - DEVILS-STAIRCASE
KW - LYAPUNOV EXPONENTS
KW - FRACTAL DIMENSION
KW - MODE-LOCKING
KW - DYNAMICS
KW - ENTRAINMENT
U2 - 10.1016/j.cels.2021.03.003
DO - 10.1016/j.cels.2021.03.003
M3 - Review
C2 - 33887201
VL - 12
SP - 291
EP - 303
JO - Cell Systems
JF - Cell Systems
SN - 2405-4712
IS - 4
ER -
ID: 271685254