Coupled oscillator cooperativity as a control mechanism in chronobiology
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Coupled oscillator cooperativity as a control mechanism in chronobiology. / Heltberg, Mathias S.; Jiang, Yuanxu; Fan, Yingying; Zhang, Zhibo; Nordentoft, Malthe S.; Lin, Wei; Qian, Long; Ouyang, Qi; Jensen, Mogens H.; Wei, Ping.
In: Cell Systems, Vol. 14, No. 5, 17.05.2023, p. 382-391.e5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Coupled oscillator cooperativity as a control mechanism in chronobiology
AU - Heltberg, Mathias S.
AU - Jiang, Yuanxu
AU - Fan, Yingying
AU - Zhang, Zhibo
AU - Nordentoft, Malthe S.
AU - Lin, Wei
AU - Qian, Long
AU - Ouyang, Qi
AU - Jensen, Mogens H.
AU - Wei, Ping
N1 - Publisher Copyright: © 2023 Elsevier Inc.
PY - 2023/5/17
Y1 - 2023/5/17
N2 - Control of dynamical processes is vital for maintaining correct cell regulation and cell-fate decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge of how one oscillator behaves when stimulated by two or more external oscillatory signals is still missing. We explore this problem by constructing a synthetic oscillatory system in yeast and stimulate it with two external oscillatory signals. Letting model verification and prediction operate in a tight interplay with experimental observations, we find that stimulation with two external signals expands the plateau of entrainment and reduces the fluctuations of oscillations. Furthermore, by adjusting the phase differences of external signals, one can control the amplitude of oscillations, which is understood through the signal delay of the unperturbed oscillatory network. With this we reveal a direct amplitude dependency of downstream gene transcription. Taken together, these results suggest a new path to control oscillatory systems by coupled oscillator cooperativity.
AB - Control of dynamical processes is vital for maintaining correct cell regulation and cell-fate decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge of how one oscillator behaves when stimulated by two or more external oscillatory signals is still missing. We explore this problem by constructing a synthetic oscillatory system in yeast and stimulate it with two external oscillatory signals. Letting model verification and prediction operate in a tight interplay with experimental observations, we find that stimulation with two external signals expands the plateau of entrainment and reduces the fluctuations of oscillations. Furthermore, by adjusting the phase differences of external signals, one can control the amplitude of oscillations, which is understood through the signal delay of the unperturbed oscillatory network. With this we reveal a direct amplitude dependency of downstream gene transcription. Taken together, these results suggest a new path to control oscillatory systems by coupled oscillator cooperativity.
KW - coupled oscillators, entrainment, phase modulation, biological oscillation, synthetic biology, Arnold tongues, chronobiology, NF-κB, signaling dynamics
U2 - 10.1016/j.cels.2023.04.001
DO - 10.1016/j.cels.2023.04.001
M3 - Journal article
C2 - 37201507
AN - SCOPUS:85158821592
VL - 14
SP - 382-391.e5
JO - Cell Systems
JF - Cell Systems
SN - 2405-4712
IS - 5
ER -
ID: 356890907