Coupled oscillator cooperativity as a control mechanism in chronobiology
Research output: Contribution to journal › Journal article › Research › peer-review
Control of dynamical processes is vital for maintaining correct cell regulation and cell-fate decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge of how one oscillator behaves when stimulated by two or more external oscillatory signals is still missing. We explore this problem by constructing a synthetic oscillatory system in yeast and stimulate it with two external oscillatory signals. Letting model verification and prediction operate in a tight interplay with experimental observations, we find that stimulation with two external signals expands the plateau of entrainment and reduces the fluctuations of oscillations. Furthermore, by adjusting the phase differences of external signals, one can control the amplitude of oscillations, which is understood through the signal delay of the unperturbed oscillatory network. With this we reveal a direct amplitude dependency of downstream gene transcription. Taken together, these results suggest a new path to control oscillatory systems by coupled oscillator cooperativity.
Original language | English |
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Journal | Cell Systems |
Volume | 14 |
Issue number | 5 |
Pages (from-to) | 382-391.e5 |
Number of pages | 16 |
ISSN | 2405-4712 |
DOIs | |
Publication status | Published - 17 May 2023 |
Bibliographical note
Publisher Copyright:
© 2023 Elsevier Inc.
- coupled oscillators, entrainment, phase modulation, biological oscillation, synthetic biology, Arnold tongues, chronobiology, NF-κB, signaling dynamics
Research areas
ID: 356890907