TY - JOUR

T1 - Filopodia

T2 - integrating cellular functions with theoretical models

AU - Ruhoff, Victoria Thusgaard

AU - Leijnse, Natascha

AU - Doostmohammadi, Amin

AU - Bendix, Poul Martin

N1 - Funding Information: P.M.B. acknowledges funding from the Novo Nordisk Foundation (grant nos. NFF20OC0065357 and NFF20OC0061176). A.D. acknowledges funding from the Novo Nordisk Foundation (grant no. NNF18SA0035142 and NERD grant no. NNF21OC0068687), Villum Fonden grant no. 29476, and the European Union via the ERC-Starting Grant PhysCoMeT, grant no. 101041418. The authors declare no competing financial interests. Funding Information: This work is financially supported by the Novo Nordisk Foundation . P.M.B. and V.T.R. are funded by grant nos. NNF20OC0065357 and NNF20OC0061176 . A.D. and N.L. are funded by ERC-Starting Grant PhysCoMeT no. 101041418 . Publisher Copyright: © 2024 Elsevier Ltd

PY - 2024

Y1 - 2024

N2 - Filopodia, widely distributed on cell surfaces, are distinguished by their dynamic extensions, playing pivotal roles in a myriad of biological processes. Their functions span from mechanosensing and guidance to cell–cell communication during cellular organization in the early embryo. Filopodia have significant roles in pathogenic processes, such as cancer invasion and viral dissemination. Molecular mapping of the filopodome has revealed generic components essential for filopodia functions. In parallel, recent insights into biophysical mechanisms governing filopodia dynamics have provided the foundation for broader investigations of filopodia's biological functions. We highlight recent discoveries of engagement of filopodia in various stages of development and pathogenesis and present an overview of intricate molecular and physical features of these cellular structures across a spectrum of cellular activities.

AB - Filopodia, widely distributed on cell surfaces, are distinguished by their dynamic extensions, playing pivotal roles in a myriad of biological processes. Their functions span from mechanosensing and guidance to cell–cell communication during cellular organization in the early embryo. Filopodia have significant roles in pathogenic processes, such as cancer invasion and viral dissemination. Molecular mapping of the filopodome has revealed generic components essential for filopodia functions. In parallel, recent insights into biophysical mechanisms governing filopodia dynamics have provided the foundation for broader investigations of filopodia's biological functions. We highlight recent discoveries of engagement of filopodia in various stages of development and pathogenesis and present an overview of intricate molecular and physical features of these cellular structures across a spectrum of cellular activities.

KW - cell communication

KW - cell invasion

KW - cell motility

KW - filopodia dynamics

KW - filopodia rotation

KW - mechanosensing

U2 - 10.1016/j.tcb.2024.05.005

DO - 10.1016/j.tcb.2024.05.005

M3 - Review

C2 - 38969554

AN - SCOPUS:85197629268

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

ER -